信号转导和转录激活因子3在神经发育和神经再生中的作用

Role of signal transducer and activator of transcription 3 in neuronal development and regeneration

背景信号转导和转录激活因子（signal transducers and activators of transcription，STAT）3是一种存在于中枢和外周神经系统中调节广泛生物作用的转录因子，是信号转导和转录激活因子家族的7个成员之一。目的对STAT3在神经发育和神经损伤后再生中的作用和可能的机制作一综述。内容STAT3经由神经损伤释放出的多种细胞因子、自由基、炎症调节物活化，转录入核诱导相应的靶基因，提供神经保护作用。趋势STAT3有望成为今后治疗神经缺血损伤和神经病理性疼痛新的治疗靶点。

Background Signal transducers and activators of transcription 3 （STAT3） is one of the seven members of the STATs family and mediates a wide variety of biological functions in the central and peripheral nervous systems. Objective To provide a review about the role and the possible mechanisms of STAT3 in neuronal development and regeneration. Content STAT3 is activated in response to the multiple cytokines, free radicals and other inflammatory mediator that are produced in damaged neural tissue. Activated STAT3 translocates to the nucleus, binds to the specific promoters of target genes, and induces gene expression, leads to neuroprotection. Trend Defining the endogenous molecular mechanisms that lead to neuroprotection by STAT3 after injury might identify novel therapeutic targets against neural tissue ischemic damage and neuropathic pain.