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γ—氨基丁酸受体和神经发生 被引量：1

γ-aminobutyric acid receptors and neurogenesis
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摘要 背景近年的研究显示γ-氧基丁酸（γ-aminobutyric acid，GABA）-ABA。受体通路与神经发生有密切联系。神经发生不仅存在于胎儿期和新生儿期，同时还存在于成年期。大脑海马区的神经发生状态与认知和学习记忆功能成正比。目的通过阐述GABAA受体和神经发生的关系，进而探讨与GABAA受体密切相关的全身麻醉药物的临床药理。内容主要关注GABAA受体、神经发生和认知功能之间的关系及其介导机制。趋向系统的研究GABAA受体和神经发生关系将为全身麻醉药对认知功能影响的研究提供新的思路。 Background Recent researches have revealed the intimate relationship between γ-aminobutyric acid （GABA）-GABAA receptors pathway and neurogenesis. Neurogenesis occurs not only in fetal and neonatal period but in adult. The neurogenesis in hippocampus has an intimate relationship with cognitive function and memory. Objective To investigate the relationship between the GABAA receptors and the neurogenesis, explore the pharmacology of general anesthetics works through the GABAA. Content This review is mainly focused on the relationship between the GABAA receptors and the neurogenesis and the underlying mechanism. Trend Systematic studies focused on the relationship between the GABAA receptors and the neurogenesis will provide new ideas regarding the studies of the effects of general anesthetic on the cognitive function.
作者 赵三军 朱亚静 米卫东
机构地区 北京解放军总医院麻醉科 南开大学医学院
出处 《国际麻醉学与复苏杂志》 CAS 2012年第7期474-476,共3页 International Journal of Anesthesiology and Resuscitation
基金 国家自然科学基金（30571791）
关键词 GABAA受体 神经发生 全身麻醉药 Receptors,GABAA Neurogenesis Anesthetics, general
分类号 R614 [医药卫生—麻醉学]
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参考文献16

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同被引文献18

  • 1刘立公,顾杰,刘婕,沈雪勇.古代文献中督脉及其腧穴主治的统计报告[J].针灸临床杂志,2010,26(5):43-45. 被引量：40
  • 2Levenga J, de Vrij FM, Oostra BA, et al. Potential therapeutic interventions for fragile X syndrome. Trends Mol Med. 2010; 16(11):516-527.
  • 3Pieretti M, Zhang FP, Fu YH, et al. Absence of expression of the FMR-1 gene in fragile X syndrome. Cell. 1991 ;66(4): 817-822.
  • 4IliffAJ, Renoux A J, Krans A, et al. Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice. Hum Mol Genet. 2013;22(6): 1180-1192.
  • 5Kimura I, Nakayama Y, Zhao Y, et al. Neurotrophic effects of neudesin in the central nervous system. Front Neurosci. 2013;7:111.
  • 6Budnik V, Salinas PC. Wnt signaling during synaptic development and plasticity. Curr Opin Neurobiol. 2011 ;21 (1): 151-159.
  • 7D'Hulst C, Kooy RF. The GABAA receptoi~: a novel target for treatment of fragile X? Trends Neurosci. 2007;30(8):425-431.
  • 8Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 5th ed. London: Academic Press,2005.
  • 9杜静.神经营养因子和细胞因子在介导针灸效应中的作用[J].针刺研究,2008,33(1):37-40. 被引量：11
  • 10徐琴,竺智伟,赵正言.脆性X综合征树突棘形态发育研究进展[J].神经解剖学杂志,2009,25(5):587-590. 被引量：7

二级引证文献4

国际麻醉学与复苏杂志
2012年 第7期

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