黄芪与丹参注射液对慢性肾炎气虚血瘀证临床疗效比较

Comparison of Clinical Effect of Huangqi Injection and Danshen Injection for Chronic Glomerulonephritis

目的:探讨中药制剂黄芪注射液和丹参注射液对慢性肾小球肾炎气虚血瘀证蛋白尿、肾功能、细胞免疫功能、尿FDP等的影响及比较。方法:严格按照要求选择入选病例,采用随机双盲法随机分为黄芪组、丹参组、对照组,每组各30例。黄芪组、丹参组:基础治疗基础上用黄芪注射液、丹参注射液各40mL﹢5%GS(或GNS250mL)VD30gtt/min,日1次;对照组:基础治疗的基础上加用细胞色素C15mg、辅酶100U、三磷酸腺苷20mg+5%GS(或GNS250mL)VD30gtt/min,日1次,每个疗程1个月连续观察3个月。结果:黄芪、丹参均具有降低尿蛋白、降低肌酐、尿素氮、提高免疫功能等作用,从而提高临床疗效。结论:黄芪、丹参防治慢性肾小球肾炎具有广阔的前景。

Objective： Study and compare the influence on albuminuria, renal fimction, cellular immune function, urine FDP of Chinese medicine preparation about Huangqi injection and Danshen injection for chronic glomerulonephritis of syndrome of qi deficiency with blood stasis. Methods ： We chose the cases strictly according to the standard. This investigation used randomized controlled trial and double blinding. Group of Huangqi injection had 30 cases, group of Danshen Injection had 30 cases and group of control had 30 cases respectively. Group of Huangqi injection： Huangqi injection 40mL＋5%GS （ or GNS250mL ） VD30gtt/min, qd plus basic therapy; group of Danshen injection： Danshen injection 40mL＋5%GS （ or GNS250mL ）~D30gtt/min, qd plus basic therapy group of control： basic therapy plus cytochrome C15mL＋CoAlOOU＋ATP20mg＋5%GS （orGNS 250mL ）VD30gtt/min, qd, observing for 3 months and 1 month made up of a course. Results ： These results show that Huangqi injection and Danshen injection can improve immunological function, reduce albuminuria, reduce BUN and Ser, decrease clinical syndrome. Conclusion： Huangqi injection and Danshen injection have wide foreground in prevention and treating chronic glomerulonephritis.