半合成人胰岛素治疗糖尿病的效果

THE THERAPEUTIC EFFECT OF HUMAN INSULIN IN DIABETES MELLITUS

本文观察到原用国产猪胰岛素治疗的成年糖尿病病人在换用半合成人胰岛素6个月后,日平均胰岛素剂量减少(P=0.09),空腹及餐后2小时血糖较换药前低(P<0.05);对照组均无明显改变。用人胰岛素者约半数病人血清胰岛素抗体逐渐下降;对照组大多继续上升。低血糖反应发生率两组相当。结果表明,人胰岛素的临床效果优于国产猪胰岛素,此与前者的免疫原性较低有密切关系。

The domestic porcine insulin was replaced by semisynthetic human insulin in the treatment of adult-onset diabetics. After 6 months, the dose of insulin needed decreased and the fasting and 2-hour post-prandia) blood glucose lowered as compared with those still using porcine insulin (P = 0.09, P<0.05 respectively). The insulin antibody gradually decreased in nearly half of the patients using human insulin and continuously increased in the patients using porcine insulin. The incidence of hypoglycemia was roughly the same. The results showed that the effect of human insulin is better than that of porcine insulin and it is because the human insulin is less immunogenetic. ,