疏肝颗粒对大鼠四氯化碳慢性肝损伤的药理研究

The effect of Shugan particles chronic liver injury in rats with carbon tetrachloride

目的:观察疏肝颗粒对大鼠四氯化碳慢性肝损伤的治疗作用。方法:选用体重140-180 gSD大鼠,随机分为空白组、模型组、疏肝颗粒低、中、高剂量组,大鼠皮下注射40%四氯化碳色拉油溶液,第1次按0.5 mL/l00 g,以后每次按0.3 mL/100g给予,每周2次,连续8周,造模后连续给药21 d后,腹主动脉取血,检测血清中AST、ALT、ALB、TP、甘油三酯、胆红素和碱性磷酸酶含量。结果:疏肝颗粒低、中、高剂量均能降低四氯化碳致大鼠慢性肝脏损伤模型血清AST、ALT含量(P<0.01),疏肝颗粒高剂量能升高血清ALB和TP含量,降低血清中甘油三酯、胆红素和碱性磷酸酶的含量(P<0.01)。结论:疏肝颗粒具有良好的保肝降酶作用。

Objective：To observe the therapeutic effect of the of Shugan particles chronic liver injury in rats with carbon tetrachloride.Methods： Weight 140-180 g SD rats were randomly divided into normal group,model group,liver particles,high-dose group,subcutaneous injection of 40% carbon tetrachloride salad oil solution in a 0.5 mL/l00 g,and each subsequent 0.3 mL/100 g given two times a week for 8 weeks,administration 21 days after modeling,abdominal aortic blood serum of AST,ALT,ALB,the TP,glycerol three esters,bilirubin and alkaline phosphatase.Results： Shugan particles,in high doses can reduce carbon tetrachloride induced chronic liver injury model of serum AST,ALT content（P〈0.01）,the Shugan particles high dose elevated serum levels of ALB and TP content,reduce serum triglycerides,bilirubin,and alkaline phosphatase（P〈0.01） Conclusion： Liver particles has Significant effect.