血清骨保护素与冠状动脉病变程度的关系研究

Relationship between serum osteoprotegerin levels and severity of coronary artery lesion in patients with coronary heart disease

目的探讨血清骨保护素与冠状动脉病变严重程度的关系。方法对70例因胸痛入院的患者均行冠状动脉造影检查,按结果分为正常对照组、单支、双支、多支病变四组,用酶联免疫吸附试验(ELISA)法检测血清骨保护素,同时收集患者的一般临床资料及相应生化指标,并进行多因素Logistic回归等分析。结果与对照组相比,冠状动脉有病变患者血清骨保护素水平明显增加,差异有统计学意义(P<0.001);血清骨保护素水平随冠状动脉病变支数增加明显升高,冠状动脉病变支数越多,血清骨保护素水平升高越明显,差异有统计学意义(P<0.001)。多元回归分析示:骨保护素与血管病变支数独立正相关(P<0.001),Logistic分析示:骨保护素与冠心病独立正相关(OR1.011,95%CI1.006～1.016,P<0.001)。骨保护素与Gensini评分正相关(r=0.623,P<0.001)。结论血清骨保护素水平与冠状动脉疾病的发生、进展及严重程度有直接关系。

Objective To investigate the relationship between serum osteoprotegerin （OPG）levels and the severity of coronary artery disease. Methods 70 patients with chest pain were collected in Air Force General Hospital and then underwent coronary angiography（CAG）. They were divided into four groups according to the CAG： normal control group, single, double and multi-vessel coronary artery lesion. Serum OPG were measured by enzyme linked immunosorbent assay （ELISA）. General clinical data of patients and the corresponding biochemical parameters were collected. Data were analyzed with multiple linear regression method. Results Compared with the control group,serum OPG levels in patients with coronary artery lesions were significantly increased （P 〈 0. 001 ）. As the number of diseased vessels increasing, there was a significant increase in serum OPG levels （P 〈 0. 001 ）. Multiple regression analysis showed： a positive relation was found between OPG levels and the number of diseased vessels （P 〈 0. 001 ）. Logistic analysis showed： there was a positive relation between OPG and coronary heart disease （OR = 1.011,95% CI：1. 006-1. 016 ,P 〈 0. 001 ）. OPG positively correlated with Gensini score （ r = 0. 623, P 〈 0. 001 ）. Conclusions Serum OPG levels are directly related with the progression and severity of coronary artery disease.