肝脏慢性病毒感染对结直肠癌肝转移发生及生存影响

Effect of chronic hepatic virus infection on colorectal cancer liver metastases and survival

目的探讨肝脏慢性病毒感染对结直肠癌肝转移发生率影响,分析感染者和无感染者病例总体生存情况。方法回顾性研究2868例结直肠病例,根据外周血检测结果分为感染组和无感染组,比较两组患者肝转移发生率,分析两组患者总体生存情况及比较两组肝转移患者生存时间。结果两组病例肝转移发生率比较差异有统计学意义(P<0.05),5年总体生存率感染组优于无感染组,肝转移伴病毒感染组中位生存期26个月,无感染组20个月,两组比较差异有统计学意义(P<0.001)。结论肝脏慢性病毒感染可降低结直肠癌肝转移发生率,有肝脏慢性病毒感染者病例总体预后优于无感染组,肝转移患者伴肝脏慢性病毒感染预后较好。

Objective To investigate the effect of chronic hepatic virus infection on colorectal cancer liver metastases,and analysis the survival between infected group and non-infected group. Methods 2868 colorectal cancer patients were retrospectively analyzed. According to the peripheral blood test, patients were divided into infected group and non-infected group. The incidence of liver metastases and survival were compared, patients with liver metastases survival time were also compared. Results Significant differences were found between two groups （P 〈 0. 05 ）, 5 years overall survival in infected group were better than control group. Colorectal cancer liver metastases with hepatic virus infection showed the median survival time 26 months, while the non-infected group 20 months. Conclusions Chronic hepatic virus infection decrease the risk of colorectal cancer liver metastases, also show the better oncology outcome for these patients. Colorectal cancer liver metastases with hepatic infection show better prognosis and longer survival time.