血清生长介素水平对内分泌性矮小儿的诊断价值

THE DIAGNOSTIC VALUE OF SERUM SOMATOMEDIN-C LEVELS IN PATIENTS WITH ENDOCRINE SHORT STATURE

本文报告102例矮小病人血清生长介素(SM-C)水平及其对生长激素缺乏症(GHD)的诊断价值。51例单纯GHD患者血清SM-C水平为0.14±0.18kU/L,GHD合并甲低和GHD继发于脑肿瘤的11例病人血清SM-C水平分泌为0.09±0.06和0.09±0.08kU/L,与单纯GHD者无差别,均明显低于正常同龄儿童。34例GH正常矮小儿童血清SM-C水平0.89±0.98kU/L,高于GHD患儿水平而低于正常同龄儿童。本文提出1～8岁儿童血清SM-C水平<0.15kU/L、9～17岁者<0.45kU/L应高度怀疑GHD。

This article reports the serum somatomedin-C (SMC) levels in 102 patients with short stature. The serum SMC levels of patients with idiopathic growth hormone deficiency (IGHD, n = 51) ,IGHD + hypothyroidism (n = 6) and GHD secondary to tumors in sellar region (n = 5) were 0.14±0.18, 0.09±0.06 and 0.09 ±0.08 kU/L respectively, and were statistically lower than that of normal children with the same age and sex. The serum SMC level of 34 patients with short stature but normal GH response to stimulation (serum GH peak, 5 μg/L) was 0.89±0.98 kU/L and was statistically higher than patients with GHD and lower than normal children. It was concluded that if the serum SMC levels were below 0.15 kU/L and 0.45 kU/L in children of 1-8 and 9-17 years old respectively,it strongly indicates GH secretion, defects.