摘要
越来越多的证据表明,自噬是结核免疫反应的重要组成部分。自噬可以杀灭结核分枝杆菌、调节促炎细胞因子的分泌、增加抗原递呈功能。自噬与其他抗菌途径如维生素D3、炎性体、泛素系统存在协同作用。另一方面,结核分枝杆菌可以调控巨噬细胞的自噬。目前,自噬已成为临床重要的诊疗靶点。其能诱导自噬的药物,可以作为佐剂治疗耐药性结核;能有效诱导自噬的疫苗,可能提供更好的免疫保护作用。
A growing body of evidence shows that autophagy is an essential component in the immune response to Mycobacterium tuberculosis (Mtb). Autophagy, a direct mechanism of killing intracellular Mycobacterium tuberculosis, acts as a modulator of proinflammatory cytokine secretion and plays a key role in antigen presentation. Autophagy coordinate with other host immune strategies against mycobacteria, including vitamin D-mediated innate immunity, ubiquitin-and inflammasome-involved pathways. On the other hand, Mtb has its strategies to modulate the autophagy in macrophage. Autophagy offers an attractive therapeutic target. Autophagy-promoting agents could have a clinical application as adjunctive treatment for drug-resistant tuberculosis. Moreover, vaccines which effectively induce autophagy could be more successful in providing better immune protection.
出处
《国际免疫学杂志》
CAS
2012年第4期249-254,共6页
International Journal of Immunology
基金
国家传染病重大专项资助项目(2008ZX10003-013)
国家自然科学基金资助项目(30872257)
关键词
自噬
结核分枝杆菌
免疫
Autophagy
Mycobacterium tuberculosis
Immunity