浆细胞样树突状细胞与免疫耐受

Plasmacytoid dendritic cells and immune tolerance

浆细胞样树突状细胞（PDC）来源于淋巴系干细胞，其表面标志、功能有别于髓系DC，不仅在抗病毒免疫中发挥重要作用，而且通过多种途径诱导T细胞失能和调节性T细胞的形成，从而参与免疫耐受的诱导。PDC诱导T细胞免疫耐受的分子机制与吲哚胺2，3-双加氧酶（IDO）－色氨酸代谢通路和具有抑制功能的膜分子密切相关。深入阐明PDC诱导耐受的机制，将为免疫耐受异常相关的疾病的治疗提供新方案。

Plasmacytoid dendritic cells （PDC） derive from a common lymphoid progenitor. The phenotypic features and functions of PDC are distinct from that of conventional myeloid DCs. PDC have been proven to play a important role in antiviral immune response. They also induce T cells anergy and the generation of regulatory T cells for immune tolerance. The mechanisms of immune tolerance is associated with the indoleamine 2,3-dioxygenase （IDO）-tryptophan metabolism pathway and the inhibitory membrane molecules. To elucidate the mechanisms immune tolerance induced by PDC may provide novel therapeutic approaches for diseases related to abnormal immune tolerance, such as persistent infection, tumor and autoimmune diseases.