Galectin-3在子宫内膜息肉中的表达及意义

The expression of Galectin-3 in the endometrial Polyps and the significance

目的探讨子宫内膜息肉中Galectin-3的表达及Galeetin-3与子宫内膜息肉发生的关系。方法用免疫组织化学法检测Galectin一3在绝经前后子宫内膜息肉及正常子宫内膜中的表达。其中绝经前子宫内膜息肉51例，正常子宫内膜40例；绝经后子宫内膜息肉40例，正常内膜38例。结果①Galectin-3在绝经前子宫内膜息肉及正常内膜中均有表达，绝经前子宫内膜息肉中的表达高于正常内膜，差异有统计学意义（Х^2=37．640，P〈0．01）。②Galectin-3在绝经后子宫内膜息肉及正常内膜中均有表达，绝经后内膜息肉中的表达高于正常内膜，差异有统计学意义（Х^=30．664，P〈0．01）。③Galectin-3在绝经前、后内膜息肉中的表达差异无统计学意义（Х^2=1．894，P〉0．05）。结论①Galectin-3在绝经前后内膜息肉中的高表达，提示Galectin-3可能与子宫内膜息肉的发生有关。②Galectin-3在绝经前后内膜息肉中的表达差异无统计学意义，表明绝经后内膜息肉更易恶变可能与Galectin-3无关。

Objective To observe the expression of Galectin-3 in endometrial polyps and analyze the possible relationship between Galectin-3 and endometrial polyps. Methods Immunohistochemical staining was used to observe the expression of galectin-3 in cases of premenopausal endometrial polyp, postmenopausal endo- metrial polyp and normal endometria . The samples in this study 51 cases of premenopausal endometrial polyp , 43 cases of normal premenopausal endometria , 40 cases of postmenopausal endometrial polyp, 38 cases of normal postmenopausal endometrial. Results ①The positive expression of galeetin-3 was seen in premenopausal endometrial polyps and normal endometrial. The positive expression rate was significantly higher in endometrial polyps than that in normal endometria（Х^2 = 37, 640, P 〈 0.01 ） .②The positive expression of galectin-3 was seen in postmenopausal endometrial polyps and normal endometria. The positive expression rate was significantly higher in postmenopausal endometrial polyps than that in normal postmenopausal endometria（Х^2 = 30. 664 ,P 〈 0.01 ）. ③No difference was found between the positive expression rates of galectin-3 in premenopausal and in postmenopausal endometrial polyps （Х^2 = 1. 894 , P 〉 0.05 ） o Conclusion Higher expression of galectin-3 rate in both premenopausal and postmenopausal polyps may indicate the relationship between galectin-3 and the etiology of endometrial polyp. In addition, galectin-3 is not a risk of malignant transformation in postmenopausal polyp.