子痫前期患者胎盘组织中caspase－3，8，9的表达及临床意义

Expression and clinical significance of caspase-3,8,9 in placenta of patients with preeclampsia

目的研究半胱天冬氨酸蛋白酶-3，8，9（caspase-3，8，9）在子痫前期患者胎盘中的表达及临床意义。方法选择2010年8月至2011年2月在西京医院妇产科住院分娩的孕妇40例，分为子痫前期组20例、正常妊娠对照组20例，采用免疫组化法、蛋白印迹法检测子痫前期患者和正常妊娠妇女胎盘中caspase-3，8，9的表达。结果caspase-3，8，9在子痫前期胎盘和正常妊娠胎盘中均有表达；在子痫前期患者胎盘中，caspase-3，8，9表达与正常胎盘相比显著升高（t值分剐为25．09、14．65、8．10，均P〈0．01）。结论子痫前期患者胎盘组织中caspase-3，8，9的异常表达与滋养细胞凋亡增加有关，可能是导致子痫前期发生发展的重要病理因素。

Objective To investigate the expression and clinical significance of easpase-3,8,9 in placenta of patients with preeelampsia. Methods From August 2010 to February 2011 20 preeclampsia patients （preeelampsia group） and 20 normal pregnant women （control group） hospitalized in Xijiug Hospital for delivery were selected in the study. Caspase-3,8,9 in placenta of them were detected with immunohistochemistry and western blot. Results Caspase-3,8,9 were found both in placenta of preeclampsia group and control group. The levels of caspase-3,8,9 in preeclampsia patents were significantly higher than those in control cases （t value was 25.09, 14.65 and 8.10, respectively, all P 〈 0.01 ）. Conclusion The abnormal expression of caspase-3,8,9 in the placenta of preeclampsia patients is related with the increasing of trophoblast apoptosis, which may result in pathogeuesis of preeclampsia.