子痫前期患者超敏C-反应蛋白和铁蛋白的表达

Expression of high sensitivity C-reactive protein and serum ferritin in preeclampsia patients

目的探讨子痫前期患者血清超敏C-反应蛋白（hs—CRP）和血清铁蛋白水平的变化及临床意义。方法检测80例子痫前期患者超敏C-反应蛋白及血清铁蛋白的水平。结果正常妊娠孕妇的超敏C-反应蛋白与子痫前期患者比较差异有统计学意义（t=39．063，P〈0．05）；重度子痫前期组的超敏C-反应蛋白水平与轻度子痫前期组比较差异有统计学意义（t=13．293，P〈0．05）；超敏C-反应蛋白随病情的加重逐渐升高。各组间血清铁蛋白水平均无显著性差异（均P〉0．05）。结论超敏C-反应蛋白参与了子痫前期的发生及发展，可作为其进展性的预测指标。

Objective To study the clinical changes and significance of the levels of serum high sensitivity C-reactive protein （hs-CRP） and serum ferritin （SF） in preeclampsia patients. Methods The hs-CRP and SF in 80 cases of preeclampsia patients were detected. Results There was significant difference in hs-CRP between normal patients and preeclampsia patients （t = 39. 063, P 〈0.05 ）, and there was significant difference in hs-CRP between mild preeclampsia patients and severe ones （ t = 13. 293, P 〈 0.05 ）. The level of hs-CRP gradually elevated with the increasing of severity of disease. There was no significant difference in SF between different groups （ all P 〉 0.05）. Conclusion Hs-CRP contributes to the genesis and development of preeclampsia, and it can be regarded as predictor for progression of preeclampsia