全子宫切除术后卵巢功能变化的临床观察

Clinical observation of the influence of hysterectomy on ovarian function

目的探讨子宫切除术后对女性卵巢功能的影响。方法选取北京市房山区妇幼保健院2008至2010年3年间35～50岁未绝经因子宫良性病变行全子宫切除术的病例50例作为观察组，选取同期正常体检未绝经的妇女40例作为对照组，利用微粒子化学发光法分别测定术前，术后1个月、3个月、6个月的性激素水平。结果子宫切除术后6个月观察组雌二醇，孕激素水平值显著低于术前（t=4．552、t：3．330）及对照组（t＝4．523、t=4．304），卵泡刺激素、黄体生成素值显著高于术前（t=2．377、t=4．221）及对照组（t=2．007、t=4．533），均P〈0．05。结论子宫切除后女性卵巢功能有所下降，应严格掌握子宫切除手术指征，避免治疗过度。

Objective To explore the influence of hysterectomy on ovarian function in women. Methods Fifty premenopausal women aged 35 -50 years old with uterine benign lesion undergoing hysterectomy in Maternal and Children Health Hospital of Beijing Fangshan from 2008 to 2010 were studied as observation group. Another 40 healthy women selected at simultaneous period were studied as control group. The sexual hormone level- was detected by radioimmunoassay before operation, 1 month, 3 month and 6 month after operation, respectively. Results The levels of estradiol （ E2 ） and progestin （P） in observation group at 6 month after operation were significantly lower than those before operation （t value was 4. 552 and 3. 330, respectively） and those in control group （ t value was 4. 523 and 4. 304, respectively） , and the levels of follicle- stimulating hormone （FSH） and luteinizing hormone （LH） increased significantly compared with those before operation （ t value was 2. 377 and 4. 221, respectively） and with those in control group （ t value was 2. 007 and 4. 533, respectively） （ all P 〈 0.05 ）. Conclusion The ovarian function of women undergoing hysterectomy is decreased, so the hysterectomy surgical indications should be mastered strictly in order to avoid excessive treatment.