从红细胞胰岛素受体来探讨NIDDM的病因学

THE ETIOLOGIC RESEARCH OF NIDDM USING ERYTHROCYTE INSULIN RECEPTOR

本文对非肥胖的及肥胖的NIDDM病人及其相应正常对照共四个实验组进行红细胞胰岛素受体实验,结果是Ⅰ组(非肥胖NIDDM,n=27)的高亲和力胰岛素受体结合位点数目Q_1及其亲和常数K_1(代表亲和力)为四组中最多及大;反之,Ⅱ组(肥胖的NIDDM,n=30)的Q_1及K_1为四组中最少及小。虽然在统计学上的显著性不够(由于例数偏少,s.偏大),但是可以看出趋向性,提示非肥胖NIDDM的胰岛素抵抗性与受体结合可能无关,病因可能在受体后(细胞内),而肥胖的NIDDM则相反,其病因不能排除与受体结合上的缺陷有关。

The erythrocyte insulin receptors of the four groups: non-obese and obese NIDDM with their corresponding controls were studied. Both the number of binding sites Q1 and the affinity constant Kj of the high affinity insulin receptors of the non-obese NIDDM (group I, n = 27) are the highest among the four groups. On the contrary, both the Q1 and K1 of the high affinity insulin receptor of the obese NIDDM (group II, n = 30) are the lowest. Although there is no statistically significant difference between the two groups on account of the relative scantiness of the subjects studied, the tendency is quite clear indicating that the insulin resistance of the non-obese NIDDM is not related to insulin receptor binding and most probably, it may be due to postreceptor disorder. Whereas in the obese NIDDM, defect of insulin receptor binding can not be ruled out as one of the etiologic factors.