常见蠕虫感染Th17细胞及IL-17细胞因子作用研究新进展

Advances in research on Th17 cells and IL-17 cytokines in common helminth infections

蠕虫感染在我国广泛流行,现阶段感染率有上升的趋势。蠕虫感染通过各种抗原及分泌物刺激机体产生免疫反应。Th17细胞是新发现的CD4+T细胞的亚群,其主要分泌IL-17。IL-17具有广泛的生物学效应,介导多种炎症因子及激活免疫反应。在蠕虫感染中,Th17及IL-17对宿主清除寄生虫及介导免疫病理反应起到了重要作用。本文综述了Th17及IL-17的调节机制及在常见蠕虫感染中Th17及IL-17的作用机制。

Helminth infections are widespread in China,and their rates are increasing.The body is stimulated by a variety of antigens and secretions secreted by helminths.Th17 cells are a new found subset of CD4＋ T cells and are a main source of IL-17.IL-17 has extensive biological action and can mediate diverse inflammation factors and activate the immune response.Th17 cells and IL-17 play a key role in helminth infections by removing parasites from the host＇s body and mediating an immunopathological reaction.This paper reviews the regulatory mechanisms of Th17 and IL-17 in common helminth infections.