IDDM自身抗体与胰岛功能的研究

ISLET CELL ANTIBODIES, INSULIN AUTOANTIBODIES AND ISLET β-CELL FUNCTION IN NEWLY DIAGNOSED IDDM

本文测定了36例新诊断、未使用过外源胰岛素的IDDM患者的血清胰岛细胞抗体(ICA)、血清胰岛素自身抗体(IAA)及血清C肽和胰岛素水平,并以72例新诊断的NIDDM和36例正常人作为对照。研究表明:自身免疫在IDDM病因中占有重要地位;临床发病时ICA、IAA阳性可以作为IDDM自身免疫的标志,但不能反映胰岛β细胞功能损害的程度。

The study was performed in 36 newly diagnosed IDDM patients compared with 72 newly diagnased NIDDM patients and 36 healthy controls. ICA detected by indirect immunofluorescence assay was found in 14/36 (38.9%) IDDM patients, 2/72 (2.8%) NIDDM patients and 0/36 normal controls. IAA detected with ELISA was found in 6/36 (16.7%) IDDM patients, 1/72 (1.39%) NIDDM patients and 0/36 normal controls. The incidences of ICA and IAA in IDDM were significantly higher than that in NIDDM or normal controls, (P<0.01). The serum basal C-peptide and insulin levels were not different between the ICA positive and negative groups in IDDM, (P>0.05). There was also no difference of basal C-peptide between IAA positive and negative groups in IDDM, (P>0.05). In conclusion: 1) The autoimmunity plays a remarkable etiologic role in Chinese IDDM. 2) ICA and IAA can be served as the serologic markers of autoimmunity for IDDM, but their appearance can not reflect the degree of islet cell damage at the onset of the disease.