NIDDM患者血中自由基及血清过氧化脂质及维生素E水平的观察

OBSERVATION ON THE LEVELS OF BLOOD FREE RADICALS, SERUM LIPID PEROXIDE AND VITAMIN E IN NIDDM

对19例健康人和35例NIDDM患者检测了全血自由基浓度、血清过氧化脂质和维生素E浓度。结果表明:NIDDM患者全血自由基和血清过氧化脂质水平明显高于正常对照组,有微血管病变者全血自由基水平升高更明显;血清维生素E水平无明显变化。提示NIDDM病人体内存在着自由基代谢紊乱,主要为自由基反应增强。

Concentration of blood free-radicals in 19 normal subjects and 35 patients with NIDDM was estimated by electron spin resonance spectrometer. Serum lipid peroxide (Lpo) and vitamin E were measured with biochemical methods. As compared with controls, patients with NIDDM had significantly higher blood free-radical level and serum Lpo level. The results suggested that the metabolism of free-radicals was disturbed in NIDDM.