吡啶斯的明试验对评价垂体hGH储备功能的价值

THE VALUE OF PYRIDOSTIGMINE IN EVALUATION OF GH RESERVE IN CHILDREN AND ADOLESCENTS

作者试用胆碱酯酶抑制剂吡啶斯的明兴奋hGH释放,并与胰岛素兴奋hGH试验作比较,观察了13例正常青少年和8例垂体性侏儒症患者对两种兴奋试验的反应。结果显示口服吡啶斯的明2mg/kg体重能迅速有效地兴奋垂体hGH释放,其作用较胰岛素兴奋试验更为强大,是一项值得推荐的判定青少年垂体hGH储备功能的试验。

In the present study, we observed the effects of cholinergic enhancement by pyridostigmine (PD), a cholinesterases inhibitor, on GH release in both normal (n = 13) and GH deficient children and adolescents (n = 8). Responses of GH to insulin hypoglycemia were also observed. In the normal subjects, PD-induced serum GH peak levels were significantly higher than that induced by insulin (P<0.0l). By contrast, the GH level in the patients with pituitary dwarfism showed no increase by both tests. The study indicates that PD test may be considered as a sensitive dynamic test in evaluating pituitary function of GH secretion in children and adolescents.