高压氧联合大剂量甲泼尼龙琥珀酸钠治疗脂肪栓塞综合征的疗效评价

Treatment of patients with fat embolism syndrome after trauma by hyperbaric oxygen

目的探讨高压氧联合甲泼尼龙琥珀酸钠救治创伤性脂肪栓塞综合征的疗效。方法抽取129例创伤致脂肪栓塞综合征患者,将行高压氧并联合大剂量甲泼尼龙琥珀酸钠治疗的患者26例作为治疗组,使用小剂量激素治疗患者41例为对照组。分析2组患者发病到治愈时间、住院时间、昏迷到清醒时间的差异。结果治疗组患者治愈率明显高于对照组,2组差异有统计学意义(P<0.05)。治疗组发病到治愈时间及平均住院时间较对照组明显缩短,2组差异有统计学意义(P<0.05)。2组昏迷患者治疗后昏迷到清醒时间差异无统计学意义(P>0.05)。结论高压氧联合甲泼尼龙琥珀酸钠治疗创伤性脂肪栓塞综合征疗效显著。

Objective To investigate the effect of hyperbaric oxygen （HBO） combined with Methylprednisolone （MP） in treatment of patients with fat embolism syndrome （FES） after trauma. Methods In 129 cases with FES, the 26 cases treated with HBO and large doses of MP in the treatment group, and the 41 cases treated with small doses of MP in the control group. Healing time, length of stay and duration from unconscious to the conscious were compared between two groups. Results The data showed that the cure rate in treatment group was higher than that in control group （ P 〈 0.05）. And the length of stay of treatment group was shorter than control group （P 〈 0.05）. There was no significant difference in duration from unconscious to the conscious between two groups （ P 〉 0.05 ）. Conclusion HBO combined with MP is an effective method for treatment of FES.