摘要
目的探讨不同剂量尿激酶治疗脑室出血穿刺术后血肿引流效果,从而给临床提供有意义的治疗建议。方法选取高血压脑出血并破入脑室(继发性脑室出血)患者59例,原发性脑室出血患者17例,2组均根据出血量等情况选择不同术式,2组病例情况相近,有可比性。术后分别给予3万U、5万U 2种不同剂量尿激酶溶解血凝块促进脑室内积血引出。结果治疗前2组格拉斯哥评分相近,著差无统计学意义。治疗后3 d时,尿激酶格拉斯哥评分小剂量组、中等剂量组两者比较差异无统计学意义(P>0.05);7 d后两者比较差异有统计学意义(P<0.05),并表现为治疗后2、4周时两者比较差异均有统计学意义(P<0.05)。长期日常生活能力评价,中等剂量组患者生活质量、社会行为能力较小剂量组者有显著提高(P<0.05)。结论提示中等剂量尿激酶较小剂量有更好的促进脑室积血排出、通畅脑室、减轻脑组织损害、改善预后的作用。
Objective To explore different doses of Urokinas treatment ventricle bleeding after percutaneous drainage hematoma, and to provide a meaningful clinical methods. Methods 59 patients with hypertensive intracerebral hemorrhage and broke into the ventri- cle (secondary intraventricular hemorrhage) were selected, primary ventricular hemorrhage in 17 cases, were randomly divided into two groups, selected operation according to the bleeding, and two different doses (30000 units and 50000 units) of Urokinas were given to dis- solve blood clots and promote brain hemorrhage indoor out after operation. Results There were no significant difference before treatment in Glasgow score in two groups. There were no significant differences between Glasgow score of small dose group and moderate dose treatment after three days ( P 〉 0.05 ) ; There were significant difference between Glasgow score of small dose group and moderate dose treatment after seven days, two weeks and four weeks after treatment (P 〈 0.05 ). Conclusion The moderate dose of Urokinas has better promote ventri- cle hemorrhage eduction, unobstructed ventricle, reduce the brain tissue damage, improve the function of the prognosis.
出处
《宁夏医学杂志》
CAS
2012年第6期519-520,共2页
Ningxia Medical Journal
关键词
脑室出血
尿激酶
效果
Ventricular hemorrhage
Urokinas
Effect