DNA修复基因XPA在非小细胞肺癌中的表达及其临床意义

THE EXPRESSION OF DNA REPAIR GENE XPA IN ADVANCED NON-SMALL CELL LUNG CANCER AND ITS CLINICAL SIGNIFICANCE

目的:分析非小细胞肺癌(NSCLC)组织中DNA修复基因Xeroderma Pigmentosum Group A(XPA)的表达状况及其与临床病理特征的关系。方法:采用免疫组织化学方法(IHC)检测初治中晚期NSCLC患者癌组织中XPA的表达状况,采用χ2检验比较各亚组之间的XPA表达状况的差异。结果:109例NSCLC组织中XPA的阳性表达率为55.0%(60/109),其表达与性别、吸烟史有密切关系,在男性组中的阳性率(61.0%)显著高于女性组(37.0%)(P=0.030);吸烟组的XPA阳性率显著高于不吸烟组(分别为68.1%和45.2%,P=0.017);但在吸烟人群中,吸烟量不同的亚组间XPA的表达率未见明显差异。XPA阳性率在不同年龄、临床TNM分期、组织学类型或分化程度、淋巴结转移和远处转移亚组中的差异均无统计学意义(均P>0.05)。结论:XPA在NSCLC组织中的表达状况与性别、吸烟状况密切相关,并可能与NSCLC的发生有关。

Objective：To investigate the association between the expression of DNA repair gene XPA with the clinicopathology characteristics in patients with advanced non-small cell lung cancer （NSCLC） and its clinical significance. Methods： The expression, of XPA was examined with immunohistochemistry （IHC）, the positive expression rate of XPA in different clinicopathology characteristic groups was analyzed. Re- sults： In 109 patients with NSCLC, the positive rate of XPA was 55.0% （60/109）, and the expression rate in males was significantly higher than that in females （61.0% vs. 37.0%, P =0.030）. The expression rate was also higher in smokers than in non-smokers （68.1% vs. 45.2%, P=0. 017）. There were no sig- nificant differences in the expression of XPA among different ages, TNM stages, and pathological classifi- cation （ P 〉0.05 for all）. Conclusion： In NSCLC cases, the expression status of XPA is markedly associ- ated with gender and smoking status. Thus, XPA may play a potential role in non-small cell lung cancer occur process.