扁桃体透明细胞型肌上皮癌临床病理观察

Clear cell myoepithelial carcinoma of the tonsil:a clinicopathologic observation

目的:探讨透明细胞肌上皮癌的临床病理诊断、免疫组织化学特征及其诊断与鉴别诊断。方法:对1例透明细胞肌上皮癌的组织学特征、免疫组化结果进行分析,并结合国内外相关文献进行复习。结果:患者女性,63岁,咽部梗阻感2月余月。镜下:肿瘤组织呈弥漫性浸润性生长,瘤细胞圆形或椭圆形,胞浆透明,细胞核大小不等,可见核浓染、核分裂像、核仁不明显。免疫组化显示AE1/AE3(+),CK14(+),SMA(+),P63(+),EMA(+),S100(+)GFAP(+),Ki67>10﹪。结论:肌上皮癌发生率较低,术前诊断不易考虑到,扁桃体透明细胞肌上皮癌就更罕见。因此,我们对近期发现的一例CCMC进行了临床病理分析,并对相关文献进行了复习,以加强对肌上皮癌的认识,提高诊断率。肌上皮癌对放疗不敏感,治疗以手术为主。

Objective：To study clinicopathological features, immunohistochemistry, diagnosis and differential diagnosis of Clear cell myoepithelial carcinoma.Methods：Histological features,immunohistochemical results of a clear cell myoepithelial carcinoma were analyzed, with review of the related literatures at home and abread.Resuhs ： A 63-Year-old woman presented with a 2-month history of Pharyngeal obstruction. Microseopically：the tumor is diffusely infiltrative growth pattern,and tumor cell round and oval, the cytoplasm is clear, the nucleus size differ,visible hyperehromatic nuclei and.mitoses, Lack nucleoli. The immunohistochemistry revealed the positive stain of AEI/AE3, CK14, SMA, P63, EMA, S100, GFAP, Ki67 index greater than 10%. Conclusions： Myoepithelial carcinoma incidence is low, preoperative diagnosis is not easy to consider, Clear cell myoepithelial carcinoma of the tonsil is more rare. Therefore, We have found that one of the CCMC earry out clinical pathological analysis, and the related literature review, Strengthen the understanding of the myoepithelial carcinoma,inerease diagnosis rate. myoepithelial eareinoma is not sensitive to radiation, with surgical treatment.is main.