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新抗心律失常药——决奈达隆 被引量：4

Progress on Dronedarone-a New Anti-Arrhythmia Drug
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摘要 决奈达隆(dronedarone)是由法国赛诺菲-安万特公司开发的一种新的抗心律失常药,于2009年7月获得美国FDA批准上市,用于房颤和心房扑动(AF/AFL)的抗心律失常药.它是一种无碘的苯并呋喃衍生物,其结构和药理特性与胺碘酮相似,并且无明显的甲状腺抑制作用和甲状腺激素抑制作用,不良反应少,成为新一代抗心律失常药物.就其药理作用、临床评价及不良反应等方面进行综述. Dronedarone is a new anti—arrhythmia drug,developed by Sanofi-aventis.It has been approved by FDA for the treatment of atrial fibrillation or atrial flutter in patients with heart disease on July 2009.It is a new noniodinated benzofurane derivative,which is structurally and characteristically similar to amiodarone.It has no obvious inhibition to thyroid gland and thyroid hormone,and less adverse effects.In this paper,Pharmacokinetics,clinical evaluation and adverse reactions of dronedarone are reviewed.
作者 徐利锋 姜明俊 刘举 王雪娇 王洋 陈烨 周云鹏
机构地区 辽宁大学药学院药物研究所 大连医科大学临床医学系
出处 《辽宁大学学报（自然科学版）》 CAS 2012年第2期103-109,共7页 Journal of Liaoning University：Natural Sciences Edition
关键词 决奈达隆 胺碘酮 心房颤动 抗心律失常 不良反应 dronedarone amiodarone Atrial fibrillation anti-arrhythmia adverse reactions
分类号 R963 [医药卫生—微生物与生化药学]
  • 相关文献

参考文献25

  • 1Egener FT, ehrlich JR, Hohnloser SH, et al. Droned- arone:an emerging agent with rhythm -and -rate con- lling effects[ J]. J Cardiovasc Electrophysiol, 2006,17 ($2) :17 -20.
  • 2Patel PD, Bhuriya R, Patel DD, et al. Dronedarone for atrial fibril - lation : a new therapeutic agent [ J ]. Vasc Health Risk Manag, 2009,5 (18) : 635 -642.
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二级参考文献26

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  • 7Hodeige D,Heyndrickx JP,Chatelain P,et al.SR 33589,a new amiodarone-like antiarrhythmic agent:anti-adrenoceptor activity in anaesthetized and conscious dogs[J].Eur J Pharmacol,1995,279(1):25.
  • 8Guiraudou P,Pucheu SC,Gayraud R,et al.Involvement of nitric oxide in amiodarone and dronedarone-induced coronary vasodilatation in guinea pig heart[J].Eur J Pharmacol,2004,496(1-3):119.
  • 9Celestino D,Medei E,Moro S,et al.Acute in vitro effects of dronedarone,an iodine-free derivative,and amiodarone,on the rabbit sinoatrial node automaticity:a comparative study[J].J.Cardiovasc Pharmacol Ther,2007,12(3):248.
  • 10Sun W,Sarma JS,Singh BN.Chronic and acute effects of dronedarone on the action potential of rabbit atrial muscle preparations:comparison with amiodarone[J].J Cardiovasc Pharmacol,2002,39(5):677.

共引文献2

同被引文献50

  • 1门可,李良寿.循证医学(三)——Meta分析[J].疑难病杂志,2005,4(1):58-61. 被引量：18
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  • 7Hohnloser SH,Crijns HJ,Van Eickels M,et al.Effect of dronedarone on cardiovascular events in atrial fibrillation[J].N Engl J Med,2009,360(7):668-678.
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  • 10Singh BN,Connolly SJ,Crijns HM,et al.Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter[J].N Engl J Med,2007,357(10):987-999.

引证文献4

二级引证文献17

辽宁大学学报（自然科学版）
2012年 第2期

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