HMGB1/MMP9在非小细胞肺癌中的表达及临床意义

The expression of HMGB1/MMP9 and its clinical significance in Non-Small Cell Lung Cancer

目的探讨HMGB1和MMP9在NSCLC转移过程中的作用。方法应用免疫组化S-P法检测69例非小细胞肺癌(NSCLC)和20例癌旁组织中HMGB1及MMP9的表达情况,结合临床、病理参数进行统计学分析。结果 1、HMGB1/MMP9二者在NSCLC组织的阳性表达率高于癌旁组织;两组之间差异有统计学意义(P<0.05);2、HMGB1和MMP9在非小细胞肺癌及癌旁组织中表达呈正相关。结论 HMGB1/MMP9联合检测,在NSCLC浸润转移过程中可能起协同作用,可为NSCLC诊断及判断预后提供依据。

Objective To investigate the significance of high mobility group proteinl （ HMGB1 ） and matrix metalloproteinase-9 （ MMP9 ） in the transfering process of Non-Small Cell Lung Cancer through studying their expression levels in human Non-Small Cell Lung Cancer and the paracancerous tissues in order to reveal their roles in the process of the tumor＇s invasion and metastasis. Methods The ex- pression of HMGB1/MMP9 in 69 specimens of NSCLC and 20 specimens of paracancerous tissues were determined with the immunohisto- chemical S-P method. The related data of the expression of HMGB1/MMP9 and their clinical and pathological features were statistically analyzed. Results 1. In the NSCLC group, HMGB1/MMP9 expression positive rate were higher than that in the edge of carcinoma （con- trol group）. 2. The expression of HMGB1 had a positive correlation with MMP9 in NSCLC invasion and metastasis. Conclusion By testing HMGB1/MMP9 in NSCLC and adjacent tissue, we found that both may play a synergistic role in the process of NSCLC invasion and metas- tasis. So co-examining HMGB1 and MMP9 may be providing basis for diagnosis and prognosis of NSCLC.