氨氯地平联合坎地沙坦治疗高血压晨峰的临床观察

Clinical Effects of amlodipine combined candesartan in treatment of morning blood pressure surge

目的探讨氨氯地平联合坎地沙坦对高血压患者血压晨峰的影响。方法收集80例有明确血压晨峰现象的高血压患者,随机分为观察组和对照组各40例。观察组给予马来酸氨氯地平5mg,于7:00～8:00时服用,坎地沙坦酯4mg,于20:00～21:00时服用;对照组给予马来酸氨氯地平5mg,早晨口服,1次/天,两组疗程均为8周。观察两组患者治疗前与治疗后晨峰血压下降的程度。结果观察组和对照组晨峰血压下降幅度分别为收缩压(SBP)13.20±1.09mmHg,舒张压(DBP)14.36±1.33mmHg;SBP 9.97±1.67mmHg,DBP 11.63±1.23mmHg,两组间比较差异有统计学意义(P<0.01)。结论在服用马来酸氨氯地平的同时,晚间加服坎地沙坦,能够有效控制高血压患者的晨峰现象。

Objective To investigate the impact of amlodipine combined candesartan on morning blood pressure surge in hypertension patients. Methods 80 hypertension patients with morning blood pressure surge were randomly divided into treatment group and control group, each group contained 40 cases. Treatment group received maleate amlodipine 5mg at 7 ： 00-9 ： 00, and eandesartan at 20.. 00-21 ： 00. The control group was given the maleate amlodipine 5rag at morning, orally one time per day, both group were treated for 8 weeks. The morning peak blood pressure before and after treatment was observed. Result The decrease of morning blood pressure peak of treatment and control groups were SBP 13.20± 1.09, DBP 14.36± 1.33; SBP 9.97 ± 1.67, DBP 11.63 ± 1.23, significant difference between the two groups （P〈0.01）. Conclusion Taking maleate amlodipine, and candesartan at night can effectively control the morning blood pressure surge phenomena of the hypertensive patients.