Slit-Robo信号传导通路与平滑肌细胞迁移的研究进展
摘要
平滑肌细胞(SMC)是构成人体管道组织和空腔脏器的重要成分,是构成血管壁组织结构及维持血管张力的主要细胞。Slit是一种分泌型细胞外基质蛋白,它通过其受体Roundabout(Robo)作为神经轴突导向因子和神经元迁移的排斥性因子,且在内皮细胞的迁移上也有重要作用。最近的研究发现Slit-Robo信号通路还能调控平滑肌细胞迁移,但其机制尚不清楚,现就其研究现状作一综述。
出处
《西部医学》
2012年第7期1418-1420,共3页
Medical Journal of West China
参考文献29
-
1Marks A R. Rapamycin: signaling in vascular smooth muscle [J]. Transplantation proceedings,2003,35(3) : 231-233.
-
2Itoh A, Miyabayashi T, Ohno M, et al. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possi- ble roles for Slit in the formation and maintenance of the nervous system[J]. Mol Brain Res, 1998,62 : 175-186.
-
3Zhang B, Dietrich UM, Geng JG, et al. Repulsive axon guidance molecule Slit3 is a novel angiogenic factor[J], Blood, 2009,114 (19) :4300-4309.
-
4Dong Liu, Jie Hou, Xing Hu et al. Neuronal Chemorepellent Slit2 Inhibits Vascular Smooth Muscle Cell Migration by Sup- pressing Small GTPase Rael Activation[J]. Circulation Re- search, 2006,98 : 480-489.
-
5Rothberg J M, Artavanis-Tsakonas S. Modularity of the slit protein Characterization of a conserved carboxy-terminal se- quence in secreted proteins and a motil implicated in extracellular protein interactions [C]. Journal of Molecular Biology, 1992, 227: 367-370.
-
6Hussain S, Piper M, Fukuhara Net al. A Molecular Mechanism for the Heparan Sulfate Dependence of Slit-Robo Signaling[J]. JBC,2006,281(51) : 39693-39698.
-
7William T,Gerthoffer. Moving away from the midline: new de- velopments for Slit and Robo[J]. Proceedings of The American Thoracic Society, 2008,5 : 97-105.
-
8Brose K,Biand K S, Wang K H,et al. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidanee[J]. Ceil, 1999, 96: 795-806.
-
9Morlot C, Thielens N M,Ravelli R, etal. Structural insights in- to the Slit-Robo complex[J], PNAS, 2007, 104 (38) : 14923- 14928.
-
10Bagri A, Marin O, Plump AS, et al. Slit proteins prevent mid- line crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain [J]. Neuron, 2002, 33:233-248.
-
1刘丽华,王浩宇,刘涛.Slit-Robo信号传导通路与组织损伤修复[J].心血管病学进展,2012,33(5):673-676.
-
2赵久红,易西南,赵炜,赵丹,张显芳,张海英.Slit—Robo GTPase激活蛋白在坐骨神经切断后脊神经节的表达变化[J].解剖学杂志,2011,34(1):61-64. 被引量：2
-
3李霖,卿国忠.Slit-Robo信号通路作用的研究进展[J].国际病理科学与临床杂志,2013,33(1):72-77. 被引量：2
-
4梅宇,栾天竹,王桂照,黄永麟.干扰素-γ和转化生长因子-β_1对平滑肌细胞迁移的作用[J].中国实用内科杂志,2003,23(6):361-362. 被引量：1
-
5纪素英,齐颖新,姜隽,姜晓华,姜宗来.PDGF BB、Rho-GDIα和Akt信号通路在低切应力诱导血管内皮细胞和平滑肌细胞迁移中的作用[J].医用生物力学,2009,24(S1):15-16.
-
6章杰,刘伟.平滑肌细胞的培养及应用[J].江西医药,2006,41(5):330-333. 被引量：6
-
7孔怡淳,赵堪兴.Slit-Robo信号通路及在眼部血管新生中的研究进展[J].中华眼科杂志,2014,50(5):395-398.
-
8张广平.影响血管平滑肌细胞迁移的因素[J].临床医药文献电子杂志,2014,1(18):2885-2885.
-
9瞿智玲,邓仲端.培养的动脉平滑肌细胞迁移的微孔滤膜检测法[J].中国病理生理杂志,1995,11(3):334-336. 被引量：9
-
10楚海荣,李宏,吴海燕,苏绍娟,张静,刘建华,成敏.高糖对大鼠血管平滑肌细胞迁移的影响及其机制[J].中国动脉硬化杂志,2014,22(11):1097-1100. 被引量：5
