黏蛋白MUC1、MUC2在十二指肠腺瘤的表达及意义

Expression and signifiance of MUC1 and MUC2 in duodenal adenoma

目的研究黏蛋白MUC1、MUC2在十二指肠腺瘤中的表达及意义。方法应用免疫组化方法检测了40例十二指肠腺瘤(其中9例癌变)和10例正常十二指肠黏膜MUC1和MUC2的表达。结果40例十二指肠腺瘤中,低级别异型增生9例,高级别异型增生22例,癌变9例;在十二指肠腺瘤伴低级别异型增生、高级别异型增生、腺瘤癌变中,MUC1阳性表达率分别为44.4%(4/9)、81.8%(18/22)、100%(9/9),阳性评分分别为1.33、5.86、8.67,MUC1呈逐步上调趋势(P<0.05);另一方面,MUC2的阳性表达率分别为100%(9/9)、72.7%(16/22)、11.1%(1/9),阳性评分分别为6.33、5.86、8.67,MUC2呈逐步下调趋势(P<0.05)。结论 MUC1、MUC2可能是评估十二指肠腺瘤恶性潜能的有用的标记物。

Objective To evaluate the expression and significance of MUC1 and MUC2 in duodenal adenoma. Methods The expressions of MUC1 and MUC2 were examined by immunohistochemical staining in 40 duodenal adenoma （including 9 adenoma with carcinomas）and 10 normal duodenal mucosa specimens. Results In 40 duodenal adenoma, there were 9 cases with low-grade dysplasia （ LGD ）, 22 cases with high-grade dysplasis （HGD） and 9 cases with adenocarcinomas（AC）. The positive expression rate of MUC1 were 44.4% （4/9）,81.8% （18/22）, 100% （9/9）in duodenal adenoma with LGD, HGD and AC respectively, and the score of MUC1 were 1.33,5.86,8.67 respectively, and the expression of MUC1 was up-regulation in LGD-HGD-AC （ P 〈 0.05 ） ; On the other hand, the positive expression rate of MUC2 were 100% （9/9） ,72.7% （16/22）, 11.1% （1/9）in duodenal adenoma with LGD, HGD and AC respectively,the score of MUC2 were 6.33 ~5.86,8.67 respectively, and the expression of MUC2 was down-regulation in LGD-HGD-AC. （P 〈 0. 05 ）. Conclusion MUC1 and MUC2 may be useful makers for evaluating malignant potential of duodenal adenoma.