正常成人海马磁共振定量测量研究

Quantitative measurement of the hippocampus in healthy adults on high-resolution MRI

目的测量正常成人海马体积(HCV)和T2驰豫时间(HCT2),旨在为各种与海马相关疾病的早期诊断和病情评估提供依据。方法选取18～70岁健康志愿者60例,按照年龄分成3组,每组男女各10例。所有受试者利用磁共振的三维T1加权快速梯度回波序列扫描,手工勾绘海马边界,计算双侧HCV和HCT2。利用统计学方法探讨双侧HCV和HCT2分别与年龄、性别及侧别的关系。男女间比较采用两样本t检验,左右侧比较采用配对t检验。结果所测对象中,HCV男性略大于女性,右侧大于左侧,随年龄增加逐渐减小。HCT2男女间无明显差别,双侧HCT2无明显差别,随年龄增加逐渐减小。左侧HCV/HCT2值人群90%的参考范围是26.30～36.12,右侧HCV/HCT2值人群90%的参考范围是26.88～36.77。结论利用3.0T磁共振可以获得正常成人不同年龄段的HCV和HCT2数据,为后续海马相关疾病的早期诊断提供基础数据。

Objective To measure the volume and T2 relaxation time of hippocampal formation （HPF） in healthy adults and provide database for researching on a variety of diseases associated with alteration of hippoeampal structure. Methods Sixty healthy volunteers from 18 to 70 years old were divided into 3 groups, each group contained ten males and ten females. All of the volunteers were scanned by MR using T1 weishted three-dimensional magnetization prepared rapid acquisition gradient echo sequence. The margin of HPF was outlined manually for each side, then HCV and HCT2 were measured and calculated. Using statistical methods, relationships between HCV or HCT2 and sex, age and laterality were analyzed respectively. Independent two sample t test was used to study the differences between male and female, and between left and right. Results Men had larger HCV than that of women. The right hippocampal volume was larger than the left. HCV of right side and left side were significantly negatively correlated to age. There was no significant correlation between HCT2 and sex. About the mean HCT2 of right side and left side,there was no difference. HCT2 of right side and left side were significantly negatively correlated to age. The 90% normal range ratio values of left and right HCV/HCT2 were 26.30 ～ 36. 12 and 26. 88 ～ 36. 77. Conclusion With high resolution 3.0T MRI, the HCV and HCT2 of the HPF are accurately measured, so as to provide basic data for research of hippocampus-related diseases.