白花地胆草的抗菌活性成分研究

Antibacterial Activity Components from Elephantopus tomentosus

从白花地胆草(Elephantopus tomentosus Linn.)全草的乙醇提取物中分离得到9个化合物,通过波谱分析,鉴定其结构分别为:表木栓醇(1)、羽扇豆醇(2)、6-deoxyisojacreubin(3)、桦木酸(4)、熊果酸(5)、阿魏酸(6)、3-甲酰吲哚(7)、半夏酸(8)和30-醛基羽扇豆醇(9)。所有化合物均为首次从白花地胆草中分离得到。用滤纸片琼脂扩散法测定上述化合物的抗菌活性,结果表明,化合物6和7对金黄色葡萄球菌的生长有抑制作用,化合物6和8对烟草青枯病菌的生长有抑制作用。

Nine compounds were isolated from the ethanolic extract from the whole plant of Elephantopus tomentosus Linn. On the basis of spectral data, their structures were identified as epifriedelanol （1）, lupeol （2）, 6-deoxyisojacreubin （3）, butulinic acid （4）, ursolic acid （5）, ferulic acid （6）, 3-formylindole （7）, pinellic acid （8） and 30-oxo-lupeol （9）, respectively. All compounds were obtained from Elephantopus tomentosus for the first time. Compounds 6 and 7 had inhibitory effect on Staphylococcus aureus, as well as compounds 6 and 8 exhibited inhibitory effects on Ralstonia solanacearum by paper disk diffusion method.