摘要
目的探讨脑梗死患者脑微出血一般临床因素及与同型半胱氨酸的关系。方法选择我院2011年1-12月住院的脑梗死患者90例，经三维磁敏感加权成像检查判断是否合并脑微出血，，并对患者的临床特点及同型半胱氨酸等生化指标进行分析。比较有无合并脑微出血组相关危险因素及同型半胱氨酸等生化指标是否存在差异，并进行多因素回归分析。结果脑微出血组36例，无脑微出血组54例。2组患者年龄、高血压病史、同型半胱氨酸含量差异有统计学意义（P=0．001，0．002，0．000）。多因素回归分析显示，年龄（OR=1．041，95％CI为1．00-1．08；P=0．030）、高血压病史（OR=1．101，95％CI为0．56-1．99；P=0．004）、同型半胱氨酸含量（OR=1．20，95％CI为1．10-1．32；P=0．000）与脑微出血相关。结论脑微出血与患者年龄、高血压病史、同型半胱氨酸含量相关。对于脑梗死患者合并脑微出血，更应该加强对血压、同型半胱氨酸的测定。
Objective To investigate the relation among cerebral micro-bleeds （CMBs）, cerebral cardio- vascular risk factors and homocysteine in patients with ischemic stroke. Methods Magnatic Resonance Imaging （MRI） was performed in 90 patients with acute ischemic stroke, which included susceptibility-weighted imaging. All patients received cranial magnetic resonance imaging at the first week. Homocysteine levels and other biochemi- cal parameters were measured on the next day of admission. Results Of 90 patients, 36 （40%） patients were de- tected with CMBs. Age, history of hypertension and homocysteine levels were significantly associated with the pres- ence of CMBs（P =0. 001, 0. 002, 0. 000）. Through logistic regression analysis, age（ OR = 1. 041,95% CI 1.00- 1.08 ; P = 0. 030 ）, history of hypertension （ OR = 1.101,95 % CI O. 56-1.99 ; P = 0. 004 ） and plasma homocysteine （ OR = l.20,95% Cl l. lO-1.32 ;P =O. OOO ） were inclnded in the model. Conclusion Olderage, historyofhyper- tension and level of plasma homocysteine are related to CMBs in patients with ischemic stroke.
出处
《中国医药》
2012年第7期845-847,共3页
China Medicine
关键词
脑梗塞
微出血
高血压病史
同型半胱氨酸
Brain infarction
Micro hemorrhage
History of hypertension
Homocysteine
