DLL4和VEGF蛋白在大肠癌中的表达及临床意义探讨

DLL4 and VEGF Protein Expression in Colorectal Cancer and its Clinical Significance

目的分析DLL4和VEGF蛋白在大肠癌中的表达及临床意义。方法对100例大肠癌患者组织进行DLL4和VEGF蛋白的检测,并与正常组织内检查结果进行比较,同时分析患者肿瘤大小、浸润程度及淋巴结转移的DLL4和VEGF蛋白检测结果是否存在差异。结果大肠癌组织内部的DLL4和VEGF蛋白表达更强,且患者恶性程度越高,其检测值越高,P<0.05,组间比较有显著差异。结论检测DLL4和VEGF蛋白在大肠癌中具有较好的应用价值,其能够反应患者的肿瘤恶性程度。

Objective To analyze DLL4 and VEGF protein expression in colorectal cancer and its clinical significance.DLL4 and the VEGF protein detection.Methods 100 patients with colorectal cancer tissues compared with normal tissue test results, analysis of patients with tumor size, degree of infiltration and lymph node metastasis DLL4 and VEGF protein detection results are different. Results The colorectal cancer within the organization DLL4 and VEGF protein expression more and the higher the degree of malignancy in patients with higher detection value, P〈0.05, significant difference between the two groups. Conclusion The detection DLIA and VEGF protein in colorectal cancer has good application value to reflect the patient＇s degree of malignancy.