原发性乳腺癌 p-AS160(Thr642) 水平与常用临床病理指标的相关性研究

Correlation of p-AS160(Thr642) level and clinical biological parameters in breast cancer

目的探讨乳腺癌组织中p-AS160(Thr642)水平上调与常用临床病理指标的相关性。方法采用免疫组织化学的方法检测81例原发性乳腺癌患者肿瘤组织中p-AS160(Thr642)、ER、PR、P53以及HER-2的表达水平,采用卡方检验(线性趋势性检验)比较分析p-AS160(Thr642)与淋巴结转移、pTNM分期、ER、PR、P53以及HER-2的相关性。采用Spearman检验分析p-AS160(Thr642)与患者年龄、肿瘤大小的相关性。结果 p-AS160(Thr642)与HER-2、肿瘤大小呈显著正相关(χ2=7.245,P=0.007;r=0.273,P=0.013),而与患者年龄呈显著负相关(r=-0.229,P=0.040)。结论 p-AS160分子可能是乳腺癌的一个有价值的标志物与治疗靶分子。

Objective To observe the correlation between p-AS160 （Thr642） and clinical biological parameters in breast cancer. Methods Immunohistochemical method was used to detect p-AS160 （Thr642） , estrogen receptor（ER）, progesterone receptor （PR）, P53 and HER-2 levels in tumor tissues of 81 primary breast caner patients. The association between p-AS160 levels and lymph node metastasis, pTNM stage, ER, PR, P53 and HER-2 was analyzed using Chi-square test. The association between p-AS160 （Thr642） levels and the patient＇ s age and tumor size was analyzed by the Spearman nonparametric test. Results p-AS160 （Thr642） was inversely correlated with the patient＇ s age （r=-0. 229 ,P=0. 040） and positively correlated with tumor size （r=0.273,P=0.013） and HER-2 （xz=7.245,P=0.007）. Conclusion p-AS160 （Thr642） might be useful as a marker and a potential target molecule for breast cancer.