促性腺激素释放激素激动剂联合反向添加法治疗子宫内膜异位症的临床疗效观察

The Clinical Curative Effect Observation of Gonadotropins Agent Combined Reverse Add Method in the Treatment of Endometriosis

目的:探讨短期应用促性腺激素释放激素激动剂联合反向添加疗法治疗子宫内膜异位症的临床疗效。方法:选取笔者所在计划生育服务站接受治疗的子宫内膜异位症患者62例,随机分为试验组32例和对照组30例。两组患者均在月经周期第2天起给予戈舍瑞林3.6mg皮下注射,每4周一次,共3次;试验组患者在此基础上,于第二次注射促性腺激素释放激素激动剂的同时,每天口服结合型雌激素0.625mg和安宫黄体酮2mg,至治疗结束共8周。结果:两组治疗前后血清激素和CA125、疼痛VAS评分比较差异有统计学意义(P<0.05);治疗后,试验组E2水平较对照组高,潮热症状发生率较对照组低,差异有统计学意义(P<0.05)。结论:促性腺激素释放激素激动剂联合结合型雌激素和安宫黄体酮反向添加疗法治疗子宫内膜异位症是安全有效的。

Objective ：To discuss the clinical curative effect of GnRH-a short-term application joint reverse add treatment for endometriosis. Methods ：The writer＇ s standing treated 62 patients with endometriosis were selected, and were randomly divided into the experimental group 32 cases and the control group 30 cases.The patients of two groups were in menstrual cycle up to 2 days of the gorbaehev RuiLin 3.6 mg subcutaneous injection, every 4 weekly, a total of three times ; The patients of experimental group based on this, the second time in inject.ion GnRH-a at the same time, every day with 0.625 mg of oral estrogen and progesterone 2 mg, the end of therapy to 8 weeks.Results ：the serum CA125 and hormone before and after treatment, pain VAS score difference was statistically significant（P〈0.05） ; After treatment, the experimental group E2 level was higher than control group, the incidence of hot flashes symptoms was lower the control group, difference was statistically signifieant（P〈0.05）.Couclusion ：GnRH-a combination of estrogen and Ann palace with progesterone reverse add therapy in endometriosis is safe and effective.