C反应蛋白基因多态性与脑梗死的相关性研究

Study on the Correlation of C-reactive Protein Gene Polymorphism and Cerebral Infarction

目的:通过脑梗死患者检验观察,研究C反应蛋白基因多态性与脑梗死的相关性。方法:回顾笔者所在医院2010-2011年收治的70例脑梗死患者,经过检查确诊动脉硬化性血栓性脑梗患者46例,腔隙性脑梗患者24例,将其分为血栓组和腔隙组。两组患者于入院后即抽取空腹静脉血3ml,用散射速率法测定C反应蛋白含量(hs-CRP)、总胆固醇(CHO)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、极低密度脂蛋白(VLDL)测定。为避免操作误差,均选择同一人检查。结果:两组患者入院后检查结果比较,hs-CRP和VLDL两项比较差异有统计学意义(P<0.05),其他检验项目比较差异无统计学意义(P>0.05),血栓组根据病情严重度,分为轻、中、重度,通过三组检查发现,轻、中、重度hs-CRP有递增趋势,且各程度比较,差异均有统计学意义(P<0.05)。两组患者经过平衡检验,均符合Hardy-Weinberg平衡定律。通过对比可见,血栓组CRP-717A>GAA基因型频率明显高于腔隙组;血栓组AG+GG基因型频率低于腔隙组,差异有统计学意义(P<0.05)。结论:CRP-717A>G基因多态性与脑梗死具有相关性,但限于病例人数局限,且hs-CRP受多方因素影响,检验不能代表更大层次面,但可以说明,对于脑梗死患者及早观察CRP,不但有更好确定病情指导治疗意义,还可以为预防疾病发生做预防性治疗。

Objective ：Study on the correlation of C-reactive protein gene polymorphism and cerebral infarction by examining the patients with cerebral infarction.Methods ：To review 70 cases of patients with cerebral infarction of author＇ s hospital from 2010 to 2011.46 cases of arterioloselerotic cerebral infarction, 24 cases of lacunar cerebral infarction were final diagnosised by examination, and divided into thrombosis group and lacunar group.3 ml fasting venous blood right away when the two groups of patients were admitted.To measure the C-reactive protein（hs-CRP）, total eholesterol（CHO）, triglyceride（TG）, low density lipoprotein（LDL）, high density lipoprotein（HDL）, very low density lipoprotein （VLDL） by scattering rate method.To avoid operator error, the test results were checked by the same person.Results ：Examination results of two groups of patients admitted to hospital were compared, hs-CRP and VLDL were significantly different（P〈0.05）, while the other test items were insignificant（P〉0.05）.The group of thrombosis were divided into mild, moderate or severe according to severity.There was an increasing trend in hs-CRP from mild to severe, and each degree were significantly different（P〈0.05）, when compared each other.After balancing test, the two groups ofpatients werein Hardy-Weinbergequilibrium.h＇ s showed that genotypefrequeneyofCRP-717A〉G AA of thrombosis groupwas significantly higher than that in lacunar group, AG＋GG of thrombosis group was significantly lower than that in lacunar group.Conclusion ：CRP-717A〉G gene polymorphism and cerebral infarction has A correlation, but limited to limited the number of cases, and by many hs-CRP factors, inspection does not represent A more level surface, but can explain, for patients with cerebral infarction early observation CRP, not only have A better condition guidance significance to determine treatment, can also prevent disease do preventative treatment.