抗肌集钙蛋白抗体在甲状腺相关眼病中的表达及意义

Anticalsequestrin antibodies and thyroid-associated ophthalmopathy

目的国内尚无有关血清抗肌集钙蛋白抗体与甲状腺相关眼病(thyroid-associated ophthalmopathy,TAO)的相关报道,国外研究亦较少。文中通过检测血清抗肌集钙蛋白抗体水平,初步探讨其在TAO发病中的作用及其特点。方法采用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测33例TAO患者(充血型15例、眼肌型18例)和19例甲状腺功能亢进(Graves'disease,GD)患者血清抗肌集钙蛋白抗体水平。结果 GD组(139.66±55.64)pg/ml与眼肌型眼病(ocular myopathy,OM)组(261.74±224.65)pg/ml相比,OM组抗体浓度明显升高,差异有显著性统计学意义(P<0.05),OM组与充血型眼病(congestive ophthalmopathy,CO)组(165.46±150.75)pg/ml相比,OM组抗体浓度明显升高,差异有显著性统计学意义(P<0.05)。结论 TAO患者中抗肌集钙蛋白抗体水平明显升高,尤其是在伴有眼肌病变的患者中,提示其可能与TAO的发病机制有关。

Objective As for the relation of anticalsequestrin antibodies with thyroid-associated ophthalmopathy （ TAO）, there have been very few reports abroad and even none at home. Our study was to investigate the role of anticalsequestrin antibodies in TAO. Methods We measured serum levels of anticalsequestrin antibodies by ELISA in 33 patients with TAO （ including 15 cases of congestive ophthalmopathy [ CO] and 18 cases of ocular myopathy [ OM] ） and 19 patients with Graves＇ disease （GD）. Results The mean level of anticalsequestrin antibodies was significantly increased in the OM cases （ [ 261.74 ± 224.65 ] pg/ml as compared with either the GD controls （ [ 139.66± 55.64 ] pg/ml） （ P 〈 0.05 ） or the CO cases （ [ 165.46 ± 150.75 ] pg/ml） （ P 〈 0.05 ）. Conclusion The serum level of anticalsequestrin antibodies is significantly increased in TAO patients, particularly in those with OM, which suggests that anticalsequestrin antibodies may be involved in the pathogenesis of TAO.