D-丝氨酸在手术后认知功能障碍发病机制中作用的研究进展

Progress in the research of D-serine on postoperative cognitive dysfunction pathogenesis

手术后认知功能障碍(postoperative cognitive dysfunction,POCD)是手术后老年患者常见的中枢神经系统并发症。临床表现为精神错乱、焦虑、人格改变以及记忆损害。主要发生于老年患者,属于神经退行性疾病,严重影响患者生活质量。现已证实N-甲基-D-天冬氨酸(N-methyl-D-aspartic acid,NMDA)受体与某些认知功能障碍性疾病的发病机制密切相关。文中综述NMDA受体的主要内源性配体D-丝氨酸(D-Serine,D-Ser)所致兴奋性神经毒性在认知功能障碍性疾病发病机制中的作用。

Postoperative cognitive dysfunction （POCD） is a common complication of central nervous system among the old postoperative. Its symptoms include mental disorder, personality changes and memory impairment. This phenomenon usually occurs in the elderly, belongs to the neurodegenerative diseases, it seriously impact the quality of patients＇ life. But the exact mechanism of POCD is still unknown. Previous studies have demonstrated that NMDA receptors are closely related to the pathogenesis of some cogni- tive function barrier diseases. This paper will provide an overview about the role of excitability neurotoxicity caused by D-ser, an main endogenous ligand of NMDA, in the mechanism of POCD.