摘要
目的探讨血清胱抑素C、随机尿微量白蛋白/肌酐比值在儿童肾脏损伤中的诊断价值。方法选取45名患儿为观察组,根据疾病种类将其分为肾脏疾病组和肾外疾病组。30例健康体检儿童为对照组。分别检测血清胱抑素C(SCys C)、尿素氮(BUN)、血清肌酐(SCr)、尿肌酐及尿微量白蛋白。结果肾脏疾病组、肾外疾病组SCys C与对照组之间比较差异均有统计学意义(P<0.01);随机尿微量白蛋白与尿肌酐比值(microalbumin/creatinine ratio in random u-rine,U-mAlb/Cr)在肾外疾病组与对照组比较差异有统计学意义(P<0.01)。结论 SCys C、U-mAlb/Cr对肾脏损伤的敏感性优于传统指标BUN、SCr、eGFR及尿常规。SCys C和U-mAlb/Cr联合检测更有助于肾脏损伤病因分析及提高其阳性诊断率。
Objective To evaluate the diagnostic value of serum cystatin C and microalbumin/creatinine ratio in random urine for kidney injury in children.Methods Forty-five children were enrolled in this study.They were classified into kidney disease group and non-renal disease group by types of diseases.Thirty healthy children were used as the controls.The serum cystitis C（SCysC）,blood urea nitrogen（BUN）,serum creatinine（SCr）,uric creati-nine and uric microalbumin were measured.Results Compared with the controls,the concentration of SCys C in the kidney disease group and non-renal disease group all had significant differences（P0.01）;The level of microalbumin/creatinine ratio in random urine（U-mAlb/Cr） from the non-renal disease group was higher than that from the normal children（P0.01）.Conclusion The sensitivity of SCys C and U-mAlb/Cr were significantly better than the traditional indexes of BUN,SCr,eGFR and urine routine examination in renal damage.Their combined detection can help to analyze the cause of diseases,and improve the positive diagnostic rate of kidney injury.
出处
《中华全科医学》
2012年第8期1200-1201,1244,共3页
Chinese Journal of General Practice
