期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

IL-6基因启动子多态性与COPD相关性分析 被引量：7

原文传递
导出
摘要 目的研究慢性阻塞性肺病(COPD)患者IL-6基因多态性在COPD发病机制的作用。方法提取30例COPD和30例健康者外周血DNA,扩增IL-6基因启动区2个单核苷酸多态性位点DNA序列并测序,测定IL-6血浓度。结果 COPD组与对照组血清IL-6差异有统计学意义(P<0.05);COPD组外周血IL-6基因启动区-572位点单核苷酸多态性(23.4%)与对照组(3.3%)比较,两组差异有统计学意义(P<0.05);比较COPD组中纯合突变GG型、杂合突变GC型及未出现突变三者之间的肺功能差异有统计学意义(P<0.05)。结论广东深圳汉族COPD患者IL-6基因启动区-572位点具有单核苷酸多态性,IL-6-572位点的G型等位基因可能与该地区汉族人群COPD发病有关,可能为COPD的易感基因。
作者 周爱莲 杨文昊 龙发 陈丽芳 李俊华
机构地区 广东省深圳市罗湖区人民医院呼吸内科
出处 《中华全科医学》 2012年第8期1257-1258,共2页 Chinese Journal of General Practice
关键词 慢性阻塞性肺病 白细胞介素-6基因 单核苷酸多态性 易感基因
分类号 R563 [医药卫生—呼吸系统]
  • 相关文献

参考文献10

  • 1Santos S, Peinado VI, Ramirez J, et al. Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD [ J ]. Eur Respir J,2002,19(4) :632-638.
  • 2Walter RE, Wi[k JB, Larson MG, et al. Systemic inflammation and COPD :the Framingham Heart Study [ J ]. Chest, 2008,133 ( 1 ) : 19- 25.
  • 3Guignabert C, Raffestin B, Benferhat R, et al. Serotonin transporter in- hibition prevents and reverses monocrotalineinduced pulmonary hyper- tension ir rats[J]. Circulations,2005,111 (21) :2812-2519.
  • 4van Helvoort HA, Heijdra YF, Heunks LM, et al. Supplemental oxygen prevents exerciseeinduced oxidative stress in muscle-wasted patients with chronic obstructive pulmonary disease[ J]. Am J Respir Crit Care Med,2006,173 (10) :1122-1129.
  • 5Yokoe T, Minoguehi K, Matsuo H, et al. Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syn- drome are decreased by nasa/continuous positive airway pressure[ J]. Circulation ,2003,107 (8) : 1129-1134.
  • 6Seifart C, Dempfle A, Plagens A, et al. TNF-et, TNF-13, IL-6, and IL- 10-promoter polymorphisms in patients with chronic obstructive pulmo- nary disease[ J]. Tissue Antigens ,2005,65 ( 1 ) :93-100.
  • 7Kitamura A, Hasegawa G, Obayashi H, et al. Interleukin-6 polymor- phism (-634C/G) in the promotor region and the pIogression of dia- betic nephropathy in type 2 diabetes[ J]. Diabet Med ,2002,19 (12) : 1000-1005.
  • 8Yamada Y, Ando F,Niino N, et al. Association of poiymorphisms of in- terleukin-6, osteocalcin, and vitamin D receptor genes, alone or in com- bination,with bone mineral density in community-dwelling Japanese women and men [ J ]. J Clin Endocrinol Metab, 2003,88 ( 7 ) : 3372- 33"/8.
  • 9Humphries SE, Luong LA, Ogg MS, et al. The interleukin-6-174G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthymen[ J]. Eur Heart J ,2001,22 ( 24 ) :2243-2252.
  • 10Shin KK,Jang Y,Koh SJ,et al. Influence of the IL-6-572C > G poly- morphism on inflammatory markers according to cigarette smoking in Korean healthy men [ J ]. Cytokine ,2007,39 (2) : 116-122.

同被引文献126

  • 1马志明,张珍祥,韩泽民,徐永建.慢性阻塞性肺疾病患者HO-1基因启动子微卫星多态性与凋亡的关系研究[J].中国老年学杂志,2005,25(11):1289-1292. 被引量：2
  • 2马丽,冯端兴,张湘燕,单可人,刁小源,李毅,刘维佳,万自芬,杨杰.β_2-肾上腺素能受体基因多态性与慢性阻塞性肺疾病的关系[J].中国实用内科杂志：临床前沿版,2006,26(2):267-269. 被引量：8
  • 3吴永全,王学东,方宏,王永亮,张宇晨,苏立杰.血管紧张素Ⅱ受体1、2,醛固酮合成酶与房颤心房结构重构的关系[J].中华医学杂志,2007,87(32):2281-2284. 被引量：3
  • 4黄平,马育霞,杜秀芳,陈济明,宋冰,洪永忠.慢性阻塞性肺疾病患者的维生素D结合蛋白基因多态性[J].中华结核和呼吸杂志,2007,30(10):780-781. 被引量：9
  • 5Wei YS, Zhang L, Lan Y, et al. Association of the interleu- kin 2 polymorphisms with interleukin-2 serum levels and risk of nasophayngeal eareinoma[J]. DNA Cell Biol, 2010,29 (7) = 363-368.
  • 6Huang M, Gai X, Yang X, et al. Functional polyrnorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease[J]. Clin Chem Lab Med, 2009,47(1) :32-37.
  • 7van Durme YM, Lahousse L, Verhamme KM, et al. Mendelian randomization study of interleukin-6 in chronic obstructive pulmonary disease [J]. Respiration, 2011, 82 (6): 530-538.
  • 8Chung KF. Cytokines in chronic obstructive pulmonary disease [J]. EurRespirJ, 2001, 34 (18): 50s-59s.
  • 9Venkayya R, Lain M, Willkorn M, et al. The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells [J]. Am J Respir Cell Mol Biol, 2002, 26 (2) : 202- 208.
  • 10D' amato M, Vitiani LR, Petrelli G, et al. Association of persistent bronchial hyperresponsiveness with β2-adrenoceptor (ADRB2) haplotypes~ a population study[J]. Am J Respir CritCareMed, 1998, 158 (6): 1968-1973.

引证文献7

二级引证文献74

中华全科医学
2012年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部