多次输血患者血小板抗体检测与配合型输注效果分析

Detection of Platelet Antibody with Multiple Blood Transfusions in Patients and Analysis of Matching Infusion Effect

目的分析多次输血患者血小板抗体阳性率与配合型血小板输注效果,以提高输注疗效。方法采用简易致敏血小板血清学技术(SPESA)分别比较多次输血患者(实验组)和无输血史的随机住院患者(对照组)的血小板抗体阳性率,并对血小板抗体阳性患者分别输注随机单采血小板和配型血小板,计算1 h和24 h血小板增高指数(CCI),对血小板输注效果进行比较分析。结果实验组和对照组中的血小板抗体阳性率分别为40.5%和15.1%,组间差异有统计学意义(P<0.05),且实验组中抗体阳性率与输注次数呈正相关,65例血小板抗体阳性患者输注随机血小板和52例阳性患者输注配型血小板后1 h和24 h CCI值比较,差异有统计学意义。结论多次输血导致血小板同种抗体的产生,血小板交叉配型能提高血小板输注的有效性。

Objective To analyze the repeated blood transfusion patients with positive rate of platelet antibody and evaluate the effect of platelet transfusion.Methods Platelet antibody positive rate was compared by using simplified sensitized platelet serology assay（SEPSA） in patients with repeated blood transfusions（experimental group） and without a history of blood transfusion randomized patients（control group）;the measures of platelet cross matching and calculation of 1h and 24h thrombocytosis index（CCI value） were taken on platelet antibody positive patients so that the matched type platelet effect of transfusion can be analyzed.Results The platelet antibody positive rates,with difference between groups was statistically significant（P0.05）,were 40.5% and 15.1% in experimental group and control group respectively.The experimental group antibody positive rate was positively correlated with infusion times.There was significant difference between CCI of patients platelet antibody positive infused with random platelet for 65 times and patients infused with matched platelet for 52 times.Conclusion Multiple blood transfusions can cause platelet antibody production and effectiveness of platelet transfusion can be improved with cross-matching.