玻璃体切割联合内界膜剥离治疗RVO继发黄斑水肿

Pars plana vitrectomy combined with internal limiting membrane peeling for the treatment of macular edema secondary to RVO

目的:评估玻璃体切割联合内界膜剥离治疗视网膜静脉阻塞(retinal vein occlusion,RVO)继发黄斑水肿的治疗效果。方法:对12例视网膜中央或分支静脉阻塞的患者行玻璃体切割联合内界膜剥离,记录术前术后最佳矫正视力(BCVA)及黄斑中心凹厚度。结果:术前平均黄斑中心凹厚度563.9±90.0μm,术后2mo黄斑中心凹的平均厚度为361±61.1μm,术后黄斑厚度较术前明显降低(P=0.001)。所有CRVO的BCVA均有所提高,而8例BCVO只有4例术后视力得到提高。术前平均标准对数视力表的BCVA为1.23±0.29,术后为1.06±0.49,术后与术前相比无统计学意义(P=0.09)。结论:玻璃体切割联合内界膜剥离可显著改善RVO继发的黄斑水肿,但术后视力提高不明显。

AIM： To evaluate the effects ofpars plana vitrectomy （PPV） combined with internal limiting membrane peeling for the treatment of macular edema secondary to retinal vein occlusion （RVO）. METHODS：Twelve cases of visual loss due to macular edema caused by central RVO or branch RVO underwentPPV combined with internal limiting membrane peeling. Best-corrected visual acuity （BCVA） and central foveal thickness by optical coherence tomography（OCT） were measured pre- and postoperatively then compared to assess the outcome of surgery. RESULTS： In all cases retinalthickeness diminished within 2 months of surgery. Visual acuity improved in all of the central RVO cases and 4 out of 8 branch RVO cases. The decrease in macular thickness was statistically significant （mean postoperative macular thickness 361 ± 61. 1μm versus mean preoperative macular thickness 563.9±90.01Jm, P= 0. 001, t-test）. The improvement in BCVA was not statistically significant （mean preoperative BCVA in LogMAR 1.23 ± 0.29 versus mean postoperative BCVA in LogMAR 1.06±0.49, P=0.09, t-test）. CONCLUSION： In eyes with macular edema secondary to RVO, PPV combined with internal limiting membrane peeling can resolve macular edema, but the improvement in BCVA was not statistically significant in this study.