分泌性中耳炎相关细胞因子免疫机制研究进展

Immunologic mechanism of cytokines in otitis media with effusion

近年来国内外对分泌性中耳炎相关的免疫机制进行了大量研究,尤其是I型变态反应,Th1、Th2相关的细胞因子以及这些细胞因子与肿瘤坏死因子、干扰素、核转录因子、氧自由基、缺氧与缺氧诱导因子、转化生长因子、黏附因子间的相互作用,在分泌性中耳炎免疫机制中的调节作用已经成为研究的热点,现对其研究进展做简要的综述,同时提出一些新的观点。

There were a lot of researchs performed on the immunologic mechanism related to otitis media with effusion（OME） at home and abroad in the recent years, especially the type I allergy, cytokines related to Thl/Th2 , the interactions among these cytokines and tumor necrosis factor-α （ TNF-α）, interferon-γ（ IFN-γ ）, nuclear transcription factors kappa B （ NF-kB ）, oxygen radicals, hypoxia inducible factor-1α （ HIF-1α ） , transforming growth factor-β （TGF-β）, or intercellular adhesion molecule （ICAM）. The progress was reviewed and some new ideas is to be proposed in this paper.