CO2激光联合咪喹莫特乳膏治疗甲周疣疗效观察

Comparison of CO2 laser combined with imiquimod cream and CO2 laser alone for the clinical treatment of periungual wart

目的：观察CO2激光联合咪喹莫特乳膏治疗甲周疣的临床疗效，并与单纯cO：激光治疗做比较。方法：将入选的182例甲周疣患者随机分为两组：对照组91例，单纯CO2激光手术治疗；治疗组91例，CO2激光加咪喹莫特乳膏治疗。3个月后分别对两组有效率及复发率进行随访。结果：对照组有效率84．5％，治疗组有效率90．2％，复发率分别是12．5％、7．9％。两组疗效比较，差异有统计学意义（P〈0．05）。结论：CO2激光联合5％咪喹莫特乳膏治愈率高，复发率低。联合治疗对特殊部位疣有一定推广价值。

Objective To compare the treatment of periungual wart using CO2 laser combined with imiquimod cream and using CO2 laser alone. Methods 182 cases with periungual warts were selected and randomly divided into two groups. The observation group included 91 cases, which were treated by CO2 laser plus imiquimod cream. The control group with 91 cases were treated by CO2 laser alne. All patients were followed for 3 months after the initial treatment. The cure rate and recurrence rate were compared in two groups. Results The data showed that the cure rate in control group and observation group patients was 84.5% and 90.2% （P〈0.05）, respectively. The wart recurrence rate was 12.5% and 7.9% in two group （P〈0.05）, respectively. Conclusion The high cure rate and low recurrence rate can be obtained in the treatment of periungual wart using CO2 laser combined with 5% imiquimod cream. Combination therapy for periungual parts should be promoted.