6916例头孢曲松钠不良反应报告分析

Adverse reactions of ceftriaxone sodium:Analysis of 6916 cases in Jiangsu Province

目的头孢曲松钠临床应用广泛,其不良反应越来越引起重视。文中分析总结江苏省4年来抗感染药物头孢曲松钠的不良反应发生情况及其特点,为临床合理用药提供参考。方法从江苏省药品不良反应监测中心数据库中提取2007年1月至2010年12月头孢曲松钠所致药物不良反应(adverse drug reaction,ADR)报告6916例,进行回顾性统计分析。结果 10岁以下儿童(18.65%)是高发组。头孢曲松钠所致ADR临床表现以皮肤及其附件损害最多(61.68%),其余依次是全身性损害、胃肠系统损害、药物热、神经系统损害等。结论临床应重视头孢曲松钠引起ADR的各种因素,加强对其严重不良反应的预防和监测,确保临床安全、有效、合理用药。

Objective With the wide clinical application of ceflriaxone sodium, more and more attention has been drawn to its adverse reactions. This article analyzes the characteristics of the adverse drag reactions （ADR） of ceftriaxone sodium in Jiangsu Province to provide some reference for rational and safe medication in clinical practice. Methods We retrospectively analyzed 6916 cases of adverse reactions of ceftriaxone sodium reported from Jan. 2007 to Dec. 2010 from the database of our center. Results Children under the age of 10 years was a high-risk cohort, with an ADR incidence of 18.65%. The clinical manifestations of the ad- verse reactions of ceftriaxone sodium were mostly skin lesions （61.68%）, followed by systemic problems, gastrointestinal disorders, drug fever, and central and peripheral nervous system involvement. Conclusion Attention should he paid to the muhiple factors causing serious ADRs of ceftriaxone sodium, and strengthened measures are necessitated for the prevention and control of ADRs.