登革病毒样颗粒研究概况

Progress in researches on dengue virus-like particles

病毒样颗粒(virus-like particles,VLPs)是不含病毒特异核酸的空壳结构,许多病毒结构蛋白都具有自动组装成VLPs的能力,在形态结构上与天然的病毒颗粒相似,具有很强的免疫原性和生物学活性。登革病毒(Dengue virus,DV)为黄病毒属的一员,伊蚊为其传播媒介,流行地域广泛,影响人口众多,所致疾病复杂,发病率高,目前尚缺乏有效的治疗手段和预防措施。文中对DV的组装与成熟,VLPs的产生、影响DV的VLPs产生因素,以及在研制疫苗或佐剂等方面的应用前景做一综述。

Virus-like particles （VLPs） are particles without virus-specific genetic materials. Many structure proteins of virus have the ability to assemble into virus-like particles, which are similar in structure to those of natural viruses, and can stimulate strong immunoresp0nse in the host. Dengue viruses （ DVs）, the genus of Flavivirus, are transmitted to humans through the bites of infected Aedes mosquitoes, prevail in many areas and have infected many people, causing a wide range of complicated diseases. For dengue diseases, however, there are still no effective preventive and therapeutic measures. This article focuses on the assembly and maturation of DVs, the production of VLPs and its influencing factors, and the prospect of the development and application of dengue VLP-related vaccines and adjuvants.