日本血吸虫DNA疫苗联合免疫的研究进展

Research progress on combined immunization of DNA vaccine against Schistosoma japonicum

疫苗作为预防和控制传染病的重要手段,已成功的控制了很多传染病的流行。因此,许多研究者希望研制一种安全有效的血吸虫病疫苗,以期达到控制血吸虫病流行的目的。近年来,鉴于单价疫苗有限的免疫效果,人们开始进行日本血吸虫DNA疫苗联合免疫的研究。本文对日本血吸虫DNA疫苗联合免疫的研究资料进行了归纳整理,发现日本血吸虫DNA疫苗联合免疫涉及鸡尾酒式DNA混合疫苗、双价和多价DNA联合疫苗以及佐剂研究等方面,比较减虫率、减卵率等指标,联合免疫疫苗的效果明显优于单价DNA疫苗的效果,而且具有潜在的实际应用价值。

As an important mean of prevention and control of infectious diseases, vaccine has been successfully took con- trol. Therefore, in order to control the prevalence of schistosomiasis japonica, many scientists want to develop a safe and effec tive vaccine against Schistosoma japonicum. Recently, in view of the limited immune effect of monovalent vaccine, people have started to study combined immunization of DNA vaccine of Schistosoma japonicum. This paper review the development of com- bined immunization of DNA vaccine against Schistosoma japonicum, and found that combined DNA vaccines include cocktail hybrid DNA vaccines, bivalent and multivalent DNA vaccines, and DNA vaccines with adjuvant mainly. They induced higher worm reduction rate and liver egg reduction rate, and would be well worthy of to be study.