拉莫三嗪治疗女性精神分裂症攻击行为疗效分析

An efficacy investigation of lamotrigine auxiliarilly treating female schizophrenic patients with aggressive behavior

目的:探讨氯氮平联合拉莫三嗪治疗精神分裂症患者攻击行为的疗效及安全性。方法:对36例有攻击行为的精神分裂症患者随机分为联合用药和单用药组,各18例,分别给予氯氮平联合拉莫三嗪与单一使用氯氮平治疗,疗程6周。用阳性与阴性症状量表(PANSS)、外显攻击行为量表(MOAS)和治疗中出现的症状量表(TESS)评定疗效和不良反应。结果:治疗后两组PANSS评分及MOAS评分较治疗前均显著下降(P<0.01);以联合用药组PANSS总分及阳性症状分及MOAS总分较单用药组下降显著(P<0.05),并且迅速;两组不良反应差异无统计学意义(P>0.05)。结论:氯氮平联合拉莫三嗪治疗精神分裂症攻击行为疗效好,不增加明显不良反应。

Objective To study the efficacy of clozapine combined with lamotrigine in the treatment of schizophrenic patients with aggressive behavior.Methods 36 schizophrenic patients with aggressive behavior were randomly divided into two groups,clozapine combined with lamotrigine group（combined group,n=lS） and lamotrigine group（single group,n=lS） for 6 weeks treatment.The efficacy and the safety were evaluated with positive and negative syndrome scales（PANSS）,modified overt aggression scale（MOAS） and treatment emergent symptom scale（TESS）.Results The total scores of PANSS and the scores of MOAS in both group after treatment were all signigicantly lower than those in baseline（P 〈 0.01）,the total and positive syndrome scores of PANSS and MOAS in combined group was signigJcantly lower than single group（P 〈 0.05）and more quickly.There was no signigicant difference in side effects between the two groups（P 〉 0.05）.Conclusion Clozapine combined with lamotrigine had better efficacy and no more side effect in the treatment of schizophrenic patients with aggressive behavior.