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TCR基因修饰T细胞研究进展 被引量:2

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摘要 过继细胞免疫治疗(adoptive cellular immuno-therapy,ACT)是将对抗原特异识别的细胞经体外扩增后输注入患者体内,使其被动获得特异性识别抗原能力的一种免疫疗法。该疗法在白血病、转移性黑色素瘤[1-2]、移植相关的恶性肿瘤、巨细胞病毒感染、EB病毒感染[3]等疾病中已取得了鼓舞人心的治疗效果。
出处 《中华微生物学和免疫学杂志》 CAS CSCD 北大核心 2012年第5期473-476,共4页 Chinese Journal of Microbiology and Immunology
基金 国家自然科学基金(81171539,30972680) 广东省自然科学基金重点项目(S2011020003154) 高等学校博士学科点专项科研基金(20114433110002)
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同被引文献23

  • 1叶青青,陈建思.肿瘤浸润性淋巴细胞的研究进展[J].中国医学文摘(肿瘤学),2006,20(1):76-78. 被引量:2
  • 2黄艳,张建波,江丽芳,方毅敏,余新炳,董涛,朱晓敏,方丹云,赖小敏.结核性胸膜炎胸水CD4^+与CD8^+ T细胞的TCR和CDR3谱型分析[J].中华微生物学和免疫学杂志,2007,27(9):807-809. 被引量:5
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  • 6Sadeghi B, Aghdami N, Hassan Z, et al. GVHD after chemother- apy conditioning in allogeneic transplartted rnice[J]. Bone Marrow Transplant, 2008, 42( 12): 807-818.
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  • 8Chakraverty R, C5t6 D, Buchli J, et al. An inflammatory check- point regulates recruitment of graft-versus-host reactive T cells to peripheral tissues[J]. J Exp Med, 2006, 203(8) : 2021-2031.
  • 9Li N, Chen Y, He W, et al. Anti-CD3 preconditioning separates GYL from GVHD via modulating host dendritic cell and donor T- cell migration in recipients conditioned with TBI [ J ]. Blood, 2009, 113(4) : 953-962.
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