阿尔茨海默病免疫疗法研究进展
摘要
阿尔茨海默病(AD),亦称老年痴呆症,是一种以记忆力减退、认知功能障碍、行为异常为特征的中枢神经系统退行性疾病。随着世界人口老龄化进程的加快,该病的发病率日趋增高,据估计仅在美国就有超过540万人罹患AD[1]。
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2012年第14期3106-3108,共3页
Chinese Journal of Gerontology
参考文献20
-
1Thies W, Bleiler L 2011 Alzheimer's disease facts and figures [J]. Alzheimers Dement, 2011 ; 7 ( 2 ) :208 -44.
-
2Mangialasche F, Solomon A, Winblad B, et al. Alzheimer's disease: clini- cal trials and drug development[ J]. Lancet Neuro1,2010 ;9 ( 7 ) :702-16.
-
3O'Brien RJ, Wong PC. Amyloid precursor protein processing and Alzhei- mer's disease [J]. Ann Rev Neurosci, 2011 ;34 : 185 -204.
-
4Portelius E, Price E, Brinkmalm G, et al. A novel pathway for amyloid precursor protein processing[ J]. Nenrobiol Aging,2011 ;32 (6) : 1090-8.
-
5Wang A, Das P, Switzer RC 3rd, et al. Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy [ J ]. J Neurosci, 2011 ; 31 ( 11 ) :4124-36.
-
6Lee CY, Landreth GE. The role of micmglia in amyloid clearance from the AD brain[J]. J Neural Transm,2010;ll7(8) :949-60.
-
7Zhang Y, Lee DH. Sink hypothesis and therapeutic strategies for attenua- ting Abeta levels[J]. Neumscientist,2011 ;17(2) :163-73.
-
8Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta at- tenuates Alzheimer-disease-like pathology in the PDAPP mouse [J]. Na- ture, 1999 ;400 (6740) : 173-7.
-
9Janus C, Pearson J, McLaurin J, et al. A beta peptide immunization re-duees behavioural impairment and plaques in a model of Alzheimer's dis- ease [ J]. Nature,2000 ;408 ( 6815 ) :979 -82.
-
10Morgan D, Diamond DM, Gottschall PE ,et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease [ J ]. Nature, 2000 ;408 ( 6815 ) : 982 -5.
-
1何屹.小鼠读脑仪研制成功[J].医药前沿,2013(8):27-27.
-
2风信.完成第九和第十号人类染色体完整图谱[J].知识就是力量,2004(7):70-71.
-
3日本研发早老痴呆症口服疫苗[J].中国药科大学学报,2007,38(2):148-148.
-
4美发现有害细胞“自杀”基因[J].医学研究与教育,1994,21(2):44-44.
-
5世界首个修补大脑芯片问世[J].电子产品可靠性与环境试验,2005,23(1):33-33.
-
6朱红.芹菜有助精神健康 减缓脑部疾病发展速度[J].健康伴侣,2010(2):8-8.
-
7英国建立全球首家胚胎干细胞库[J].生物学教学,2005,30(1):67-67.
-
8土豆病毒可能成阿尔茨海默氏症治疗关键[J].大众科技,2008(9):9-9.
-
9蒋平.医疗蛋白也能致命[J].中国科教创新导刊,1996,0(12):37-37.
-
10科技[J].中国医院院长,2008(6):14-14.