血清降钙素原在肝硬化并发自发性腹膜炎患者诊治中的变化

Alteration of serum procalcitonin levels in liver cirrhosis patients complicated with spontaneous bacterial peritonitis

目的观察肝硬化并发自发性细菌性腹膜炎(SBP)患者的血清降钙素原(PCT)在治疗过程中的动态变化,探讨PCT对细菌性感染疾病的诊断及预后判断价值。方法选择本院自发性腹膜炎患者55例作为治疗组,另选择病毒性肝炎患者45例作为对照组,所有患者均在入院第1、2、3、5和7天检测血清PCT水平,并将结果进行对比分析。结果血清PCT对腹膜炎诊断的敏感性为91%,差异具有统计学意义(P<0.05)。其中治疗组患者血清PCT水平在第1天开始升高,于第3天达到高峰,之后持续下降,7例死亡患者血清PCT水平持续上升。结论血清PCT测定对肝硬化并发自发性细菌性腹膜炎诊断及判断预后具有重要价值。

Objective To study the alteration of serum proealcitonin （PCT） levels in liver cirrhosis patients complicated with spontaneous bacterial peritonitis （SBP） and to analyze the value of PCT on bacterial infection diagnosis and prognosis in patients with liver cirrhosis. Methods Total of 100 cases were divided into two groups randomly. One group （n = 55 ） was liver cirrhosis patients complicated with SBP, the other group （ n = 45 ） was cases with hepatitis without SBP as control. The levels of serum PCT were detected in 100 patients, respectively. Results Serum PCT levels in the SBP infection group were significantly higher than control group and the prognosis was worse. Conclusions The alteration of serum PCT level could be used as one of the effective diagnosis index for liver cirrhosis complicated with SBP and be valuable for prognosis prediction.